Formulation and Characterization of Drug Loaded Nonionic Surfactant Vesicles (Niosomes) for Oral Bioavailability Enhancement

Table 4

Release kinetics of niosomal formulations.

Formulation code	Zero order		First order		Higuchi		Hixson-Crowell model		Korsmeyer-Peppas model
	𝑟^2	𝐾0 (h^−1)	𝑟^2	𝐾1 (h^−1)	𝑟^2	𝐾𝐻	𝑟^2	𝐾HC (h^−1/3)	𝑟^2	𝑛
F4	0.996	2.994	0.891	0.082	0.990	19.183	0.855	0.086	0.963	0.54
F9	0.997	3.343	0.942	0.126	0.986	21.333	0.899	0.118	0.967	0.53
F14	0.999	3.752	0.979	0.184	0.982	23.841	0.963	0.156	0.968	0.61
F19	0.997	3.282	0.953	0.119	0.989	20.962	0.892	0.102	0.964	0.58