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The Scientific World Journal
Volume 2014, Article ID 969404, 7 pages
http://dx.doi.org/10.1155/2014/969404
Research Article

Estrogen-Responsive Genes Overlap with Triiodothyronine-Responsive Genes in a Breast Carcinoma Cell Line

1Department of Internal Medicine, Botucatu School of Medicine, University of São Paulo State (UNESP), 18618-000 Botucatu, SP, Brazil
2Department of Radiology, Medicine School, University of São Paulo, USP, 01246-903 São Paulo, SP, Brazil
3Research Center, AC Camargo Hospital, 01509-900 São Paulo, SP, Brazil
4Department of Clinical Medicine of University of São Paulo State, Rubiao Junior District, s/n, 18618-000 Botucatu, SP, Brazil

Received 8 August 2013; Accepted 19 October 2013; Published 23 January 2014

Academic Editors: M. D. Galigniana and V. Sánchez-Margalet

Copyright © 2014 Nancy Bueno Figueiredo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. V. Jensen, G. Cheng, C. Palmieri et al., “Estrogen receptors and proliferation markers in primary and recurrent breast cancer,” Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 26, pp. 15197–15202, 2001. View at Publisher · View at Google Scholar · View at Scopus
  2. B. K. Vonderhaar and A. E. Greco, “Lobulo-alveolar development of mouse mammary glands is regulated by thyroid hormones,” Endocrinology, vol. 104, no. 2, pp. 409–418, 1979. View at Google Scholar · View at Scopus
  3. M. Lopez-Barahona, I. Fialka, J. M. Gonzalez-Sancho et al., “Thyroid hormone regulates stromelysin expression, protease secretion and the morphogenetic potential of normal polarized mammary epithelial cells,” EMBO Journal, vol. 14, no. 6, pp. 1145–1155, 1995. View at Google Scholar · View at Scopus
  4. J. M. Gonzalez-Sancho, A. Figueroa, M. Lopez-Barahona, E. Lopez, H. Beug, and A. Munoz, “Inhibition of proliferation and expression of T1 and cyclin D1 genes by thyroid hormone in mammary epithelial cells.,” Molecular Carcinogenesis, vol. 34, pp. 25–34, 2002. View at Publisher · View at Google Scholar
  5. T. Yokoe, Y. Iino, H. Takei et al., “Relationship between thyroid-pituitary function and response to therapy in patients with recurrent breast cancer,” Anticancer Research, vol. 16, no. 4, pp. 2069–2072, 1996. View at Google Scholar · View at Scopus
  6. T. Yokoe, Y. Iino, H. Takei et al., “Changes of cytokines and thyroid function in patients with recurrent breast cancer,” Anticancer Research, vol. 17, no. 1, pp. 695–699, 1997. View at Google Scholar · View at Scopus
  7. M. B. Goldman, “Thyroid diseases and breast cancer,” Epidemiologic Reviews, vol. 12, pp. 16–28, 1990. View at Google Scholar · View at Scopus
  8. D. P. Rose and T. E. Davis, “Plasma thyroid-stimulating hormone and thyroxine concentrations in breast cancer,” Cancer, vol. 41, no. 2, pp. 666–669, 1978. View at Google Scholar · View at Scopus
  9. C. Giani, P. Fierabracci, R. Bonacci et al., “Relationship between breast cancer and thyroid disease: relevance of autoimmune thyroid disorders in breast malignancy,” Journal of Clinical Endocrinology and Metabolism, vol. 81, no. 3, pp. 990–994, 1996. View at Publisher · View at Google Scholar · View at Scopus
  10. O. Takatani, T. Okumoto, H. Kosano, M. Nishida, H. Hiraide, and S. Tamakuma, “Relationship between the levels of serum thyroid hormones or estrogen status and the risk of breast cancer genesis in Japanese women,” Cancer Research, vol. 49, no. 11, pp. 3109–3112, 1989. View at Google Scholar · View at Scopus
  11. P. P. A. Smyth, D. F. Smith, E. W. M. McDermott, M. J. Murray, J. G. Geraghty, and N. J. O'Higgins, “A direct relationship between thyroid enlargement and breast cancer,” Journal of Clinical Endocrinology and Metabolism, vol. 81, no. 3, pp. 937–941, 1996. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Gogas, E. Kouskos, S. Tseleni-Balafouta et al., “Autoimmune thyroid disease in women with breast carcinoma,” European Journal of Surgical Oncology, vol. 27, no. 7, pp. 626–630, 2001. View at Publisher · View at Google Scholar · View at Scopus
  13. O. Turken, Y. NarIn, S. DemIrbas et al., “Breast cancer in association with thyroid disorders,” Breast Cancer Research, vol. 5, no. 5, pp. R110–R113, 2003. View at Google Scholar · View at Scopus
  14. M. Cristofanilli, Y. Yamamura, S.-W. Kau et al., “Thyroid hormone and breast carcinoma: primary hypothyroidism is associated with a reduced incidence of primary breast carcinoma,” Cancer, vol. 103, no. 6, pp. 1122–1128, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. H. Vorherr, “Thyroid function in benign and malignant breast disease,” European Journal of Cancer and Clinical Oncology, vol. 23, no. 3, pp. 255–257, 1987. View at Google Scholar · View at Scopus
  16. P. P. Saraiva, N. B. Figueiredo, C. R. Padovani, M. M. Brentani, and C. R. Nogueira, “Profile of thyroid hormones in breast cancer patients,” Brazilian Journal of Medical and Biological Research, vol. 38, no. 5, pp. 761–765, 2005. View at Google Scholar · View at Scopus
  17. J. M. González-Sancho, V. García, F. Bonilla, and A. Muñoz, “Thyroid hormone receptors/THR genes in human cancer,” Cancer Letters, vol. 192, no. 2, pp. 121–132, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. I. Conde, R. Paniagua, J. Zamora et al., “Influence of thyroid hormone receptors on breast cancer cell proliferation,” Annals of Oncology, vol. 17, no. 1, pp. 60–64, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. C. R. Nogueira and M. M. Brentani, “Triiodothyronine mimics the effects of estrogen in breast cancer cell lines,” Journal of Steroid Biochemistry and Molecular Biology, vol. 59, no. 3-4, pp. 271–279, 1996. View at Publisher · View at Google Scholar · View at Scopus
  20. F. Zhou-Li, V. Albaladejo, M. O. Joly-Pharaboz, B. Nicolas, and J. Andre, “Antiestrogens prevent the stimulatory effects of L-triiodothyronine on cell proliferation,” Endocrinology, vol. 130, no. 3, pp. 1145–1152, 1992. View at Publisher · View at Google Scholar · View at Scopus
  21. S. Dinda, A. Sanchez, and V. Moudgil, “Estrogen-like effects of thyroid hormone on the regulation of tumor suppressor proteins, p53 and retinoblastoma, in breast cancer cells,” Oncogene, vol. 21, no. 5, pp. 761–768, 2002. View at Publisher · View at Google Scholar · View at Scopus
  22. L. C. Hall, E. P. Salazar, S. R. Kane, and N. Liu, “Effects of thyroid hormones on human breast cancer cell proliferation,” Journal of Steroid Biochemistry and Molecular Biology, vol. 109, no. 1-2, pp. 57–66, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. S. J. Conde, R. A. M. Luvizotto, M. T. Sibio, M. L. H. Katayama, M. M. Brentani, and C. R. Nogueira, “Tamoxifen inhibits transforming growth factor-α gene expression in human breast carcinoma samples treated with triiodothyronine,” Journal of Endocrinological Investigation, vol. 31, no. 12, pp. 1047–1051, 2008. View at Google Scholar · View at Scopus
  24. R. R. Brentani, D. M. Carraro, S. Verjovski-Almeida et al., “Gene expression arrays in cancer research: methods and applications,” Critical Reviews in Oncology/Hematology, vol. 54, no. 2, pp. 95–105, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. Y. Berthois, N. Pourreau-Schneider, and P. Gandilhon, “Estradiol membrane binding sites on human breast cancer cell lines. Use of a fluorescent estradiol conjugate to demonstrate plasma membrane binding systems,” Journal of Steroid Biochemistry, vol. 25, no. 6, pp. 963–972, 1986. View at Google Scholar · View at Scopus
  26. M. A. A. Koike Folgueira, D. M. Carraro, D. F. da Costa Patrão et al., “Gene expression profile associated with response to doxorubicin-based therapy in breast cancer,” Clinical Cancer Research, vol. 11, no. 20, pp. 7434–7443, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. N. E. Willmarth and S. P. Ethier, “Amphiregulin as a novel target for breast cancer therapy,” Journal of Mammary Gland Biology and Neoplasia, vol. 13, no. 2, pp. 171–179, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. N. J. Kenney, G. H. Smith, I. G. Maroulakou et al., “Detection of amphiregulin and Cripto-1 in mammary tumors from transgenic mice,” Molecular Carcinogenesis, vol. 15, pp. 44–56, 1996. View at Google Scholar
  29. L. Martinez, J. A. Castilla, T. Gil et al., “Thyroid hormones in fibrocystic breast disease,” European Journal of Endocrinology, vol. 132, no. 6, pp. 673–676, 1995. View at Google Scholar · View at Scopus
  30. J. Frasor, F. Stossi, J. M. Danes, B. Komm, C. R. Lyttle, and B. S. Katzenellenbogen, “Selective estrogen receptor modulators: discrimination of agonistic versus antagonistic activities by gene expression profiling in breast cancer cells,” Cancer Research, vol. 64, no. 4, pp. 1522–1533, 2004. View at Publisher · View at Google Scholar · View at Scopus
  31. J. A. Vendrell, F. Magnino, E. Danis et al., “Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation,” Journal of Molecular Endocrinology, vol. 32, no. 2, pp. 397–414, 2004. View at Publisher · View at Google Scholar · View at Scopus
  32. C. J. Creighton, K. E. Cordero, J. M. Larios et al., “Genes regulated by estrogen in breast tumor cells in vitro are similarly regulated in vivo in tumor xenografts and human breast tumors,” Genome Biology, vol. 7, no. 4, article R28, 2006. View at Publisher · View at Google Scholar · View at Scopus
  33. C.-F. Qi, D. S. Liscia, N. Normanno et al., “Expression of transforming growth factor α, amphiregulin and cripto-1 in human breast carcinomas,” British Journal of Cancer, vol. 69, no. 5, pp. 903–910, 1994. View at Google Scholar · View at Scopus
  34. L. Panico, D. 'Antonio A, G. Salvatore et al., “Differential immunohistochemical detection of transforming growth factor alpha, amphiregulin and CRIPTO in human normal and malignant breast tissues,” International Journal of Cancer, vol. 65, no. 1, pp. 51–56, 1996. View at Google Scholar
  35. S. Desruisseau, J. Palmari, C. Giusti, S. Romain, P.-M. Martin, and Y. Berthois, “Clinical relevance of amphiregulin and VEGF in primary breast cancers,” International Journal of Cancer, vol. 111, no. 5, pp. 733–740, 2004. View at Publisher · View at Google Scholar · View at Scopus
  36. W. S. Argraves, L. M. Greene, M. A. Cooley, and W. M. Gallagher, “Fibulins: physiological and disease perspectives,” EMBO Reports, vol. 4, no. 12, pp. 1127–1131, 2003. View at Publisher · View at Google Scholar · View at Scopus
  37. L. M. Greene, W. O. Twal, M. J. Duffy et al., “Elevated expression and altered processing of fibulin-I protein in human breast cancer,” British Journal of Cancer, vol. 88, no. 6, pp. 871–878, 2003. View at Publisher · View at Google Scholar · View at Scopus
  38. S. M. Pupa, W. S. Argraves, S. Forti et al., “Immunological and pathobiological roles of fibulin-1 in breast cancer,” Oncogene, vol. 23, pp. 2153–2160, 2004. View at Publisher · View at Google Scholar
  39. S. M. Pupa, S. Giuffré, F. Castiglioni et al., “Regulation of breast cancer response to chemotherapy by fibulin-1,” Cancer Research, vol. 67, no. 9, pp. 4271–4277, 2007. View at Publisher · View at Google Scholar · View at Scopus
  40. A. Bardin, F. Moll, R. Margueron et al., “Transcriptional and posttranscriptional regulation of fibulin-1 by estrogens leads to differential induction of messenger ribonucleic acid variants in ovarian and breast cancer cells.,” Endocrinology, vol. 146, pp. 760–768, 2005. View at Google Scholar
  41. G. M. Clinton, C. Rougeot, J. Derancourt et al., “Estrogens increase the expression of fibulin-1, an extracellular matrix protein secreted by human ovarian cancer cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 93, no. 1, pp. 316–320, 1996. View at Publisher · View at Google Scholar · View at Scopus
  42. S. Tsukita and M. Furuse, “Occludin and claudins in tight-junction strands: leading or supporting players?” Trends in Cell Biology, vol. 9, no. 7, pp. 268–273, 1999. View at Publisher · View at Google Scholar · View at Scopus
  43. S. Offner, A. Hekele, U. Teichmann et al., “Epithelial tight junction proteins as potential antibody targets for pancarcinoma therapy,” Cancer Immunology, Immunotherapy, vol. 54, no. 5, pp. 431–445, 2005. View at Publisher · View at Google Scholar · View at Scopus
  44. Y. Soini, “Claudins 2, 3, 4, and 5 in Paget's disease and breast carcinoma,” Human Pathology, vol. 35, no. 12, pp. 1531–1536, 2004. View at Publisher · View at Google Scholar · View at Scopus
  45. Y. Soini, “Expression of claudins 1, 2, 3, 4, 5 and 7 in various types of tumours,” Histopathology, vol. 46, no. 5, pp. 551–560, 2005. View at Publisher · View at Google Scholar · View at Scopus
  46. G. Sobel, C. Páska, I. Szabó, A. Kiss, A. Kádár, and Z. Schaff, “Increased expression of claudins in cervical squamous intraepithelial neoplasia and invasive carcinoma,” Human Pathology, vol. 36, no. 2, pp. 162–169, 2005. View at Publisher · View at Google Scholar · View at Scopus
  47. Q. Wu, Y. Liu, Y. Ren et al., “Tight junction protein, claudin-6, downregulates the malignant phenotype of breast carcinoma,” European Journal of Cancer Prevention, vol. 19, no. 3, pp. 186–194, 2010. View at Publisher · View at Google Scholar · View at Scopus
  48. C. Quan and S.-J. Lu, “Identification of genes preferentially expressed in mammary epithelial cells of Copenhagen rat using subtractive hybridization and microarrays,” Carcinogenesis, vol. 24, no. 10, pp. 1593–1599, 2003. View at Publisher · View at Google Scholar · View at Scopus
  49. I. Zajc, N. Sever, A. Bervar, and T. T. Lah, “Expression of cysteine peptidase cathepsin L and its inhibitors stefins A and B in relation to tumorigenicity of breast cancer cell lines,” Cancer Letters, vol. 187, no. 1-2, pp. 185–190, 2002. View at Publisher · View at Google Scholar · View at Scopus
  50. T. Ueki, J.-H. Park, T. Nishidate et al., “Ubiquitination and downregulation of BRCA1 by ubiquitin-conjugating enzyme E2T overexpression in human breast cancer cells,” Cancer Research, vol. 69, no. 22, pp. 8752–8760, 2009. View at Publisher · View at Google Scholar · View at Scopus
  51. C.-H. Yi, D. J. Smith, W. W. West, and M. A. Hollingsworth, “Loss of fibulin-2 expression is associated with breast cancer progression,” American Journal of Pathology, vol. 170, no. 5, pp. 1535–1545, 2007. View at Publisher · View at Google Scholar · View at Scopus
  52. J. L. Fry and A. Toker, “Secreted and membrane-bound isoforms of protease ADAM9 have opposing effects on breast cancer cell migration,” Cancer Research, vol. 70, no. 20, pp. 8187–8198, 2010. View at Publisher · View at Google Scholar · View at Scopus
  53. P. Martinez, M. Thanasoula, A. R. Carlos et al., “Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites,” Nature Cell Biology, vol. 12, no. 8, pp. 768–780, 2010. View at Publisher · View at Google Scholar · View at Scopus
  54. F. Xue, Y. Zhang, F. Liu, J. Jing, and M. Ma, “Expression of IgSF in salivary adenoid cystic carcinoma and its relationship with invasion and metastasis,” Journal of Oral Pathology and Medicine, vol. 34, no. 5, pp. 295–297, 2005. View at Publisher · View at Google Scholar · View at Scopus
  55. V. Rioux, E. Beauchamp, F. Pedrono et al., “Identification and characterization of recombinant and native rat myristoyl-CoA: protein N-myristoyltransferases,” Molecular and Cellular Biochemistry, vol. 286, no. 1-2, pp. 161–170, 2006. View at Publisher · View at Google Scholar · View at Scopus
  56. K. Kishimoto, X. Yuan, H. Auchincloss Jr., A. H. Sharpe, D. A. Mandelbrot, and M. H. Sayegh, “Mechanism of action of donor-specific transfusion in inducing tolerance: role of donor MHC molecules, donor co-stimulatory molecules, and indirect antigen presentation,” Journal of the American Society of Nephrology, vol. 15, no. 9, pp. 2423–2428, 2004. View at Publisher · View at Google Scholar · View at Scopus
  57. A. Kodani, V. Tonthat, B. Wu, and C. Sütterlin, “Par6α interacts with the dynactin subunit p150Gluedand is a critical regulator of centrosomal protein recruitment,” Molecular Biology of the Cell, vol. 21, no. 19, pp. 3376–3385, 2010. View at Publisher · View at Google Scholar · View at Scopus
  58. J. E. Sadler, “von Willebrand factor assembly and secretion,” Journal of Thrombosis and Haemostasis, vol. 7, no. 1, pp. 24–27, 2009. View at Publisher · View at Google Scholar · View at Scopus
  59. A. Láng, B. Major, K. Szilágyi et al., “Interaction between separated consecutive complement control modules of human C1r: implications for dimerization of the full-length protease,” FEBS Letters, vol. 584, no. 22, pp. 4565–4569, 2010. View at Publisher · View at Google Scholar · View at Scopus
  60. A. Lacombe, H. Lee, L. Zahed et al., “Disruption of POF1B binding to nonmuscle actin filaments is associated with premature ovarian failure,” American Journal of Human Genetics, vol. 79, no. 1, pp. 113–119, 2006. View at Publisher · View at Google Scholar · View at Scopus