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The Scientific World Journal
Volume 2014, Article ID 970528, 6 pages
http://dx.doi.org/10.1155/2014/970528
Research Article

Prospective Study of BK Virus Infection in Patients with Inflammatory Bowel Disease

1Department of Digestive Diseases, General University Hospital Gregorio Marañón, Dr. Esquerdo 46, 28007 Madrid, Spain
2CIBER Hepatic and Digestive Diseases (CIBEREHD), 07110 Bunyola, Balearic Islands, Spain
3Department of Clinical Microbiology and Infectious Diseases, General University Hospital Gregorio Marañón, Dr. Esquerdo 46, 28007 Madrid, Spain
4CIBER Respiratory Diseases (CIBERES CB06/06/0058), 07110 Bunyola, Balearic Islands, Spain
5Department of Medicine, Faculty of Medicine, Complutense University of Madrid, 28040 Madrid, Spain
6Spanish Study Group on Infection in Transplant Recipients (GESITRA-RESITRA-REIPI), RD06/0008/1025, Spain

Received 11 November 2013; Accepted 24 December 2013; Published 13 February 2014

Academic Editors: D. P. Levine and A. Zakhartchouk

Copyright © 2014 Virginia Flores et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Patients with inflammatory bowel disease (IBD) have an immune-deficient baseline status further modulated by immunosuppressive therapy that may promote the reactivation of latent viruses such as BK virus (BKV). The aim of this prospective study was to determine the prevalence of BKV infection in IBD patients and its potential relationship with the immunosuppressive treatment. Paired urine and plasma samples from 53 consecutive patients with IBD and 53 controls were analyzed. BKV detection was performed by conventional PCR and positive samples were further quantified by real-time PCR. No viremia was detected. BKV viruria was significantly more common in IBD patients than among the controls (54.7% versus 11.3%; ). The only risk factor for BKV viruria in IBD was age ( versus ; ), and there was a trend towards higher rate of viruria in outpatients (61.5% versus 38.5%; ) and in those not receiving ciprofloxacin (59.5% versus 40.5%; ). A clear impact of the immunosuppressive regimen on BKV infection could not be demonstrated.