Effect of GABA_B Receptor Antagonist (CGP35348) on Learning and Memory in Albino Mice

Table 1

Comparison of the studied open field parameters between saline and CGP 35348 treated female albino mice. 𝑃 values indicate the results of two-sample 𝑡-test.

Parameters	Control female (𝑁=5)	CGP 35348 treated female (𝑁=5)	𝑃 value
Distance (m)	21.4±5.3	11.9±8.2	0.072
Mean speed (m/sec)	0.04±0.01	0.02±0.01	0.071
Time mobile (sec)	492±26.2	296.8±148.4	0.044^∗
Time immobile (sec)	108±26.2	303.3±148.4	0.044^∗
Mobile episodes	29.4±8.0	29.6±14.1	0.979
Immobile episodes	29.4±7.8	29.2±14.3	0.979
Max speed (m/sec)	0.3±0.2	0.2±0.1	0.158
Rotations	25.6±6.8	13.6±8.3	0.041^∗
Clockwise rotations	9.6±6.9	6.4±3.4	0.397
Anticlockwise rotation	16.0±1.1	7.2±5.3	0.038^∗

𝑃>0.05 = nonsignificant; 𝑃≤0.05 = least significant*.