State of the Art of Fuzzy Methods for Gene Regulatory Networks Inference

Algorithm 1

Fuzzy approach in GRN inference.

// Basic fuzzy approach for GRN Inference //

Fuzzification stage

  Define fuzzy membership values for each group

  of fuzzy sets for gene expression values from

  the microarray data.

Inference stage

  Estimate fuzzy rules related to gene

  expression with a specific optimal gene

  expression level;

  Choose rules from a fuzzy rule set to infer

  the predicted fuzzy expression profile.

Defuzzification stage

  Defuzzify inferred profile into a group of

  numbers that have the same scale of the main

  microarray data.