Table of Contents Author Guidelines Submit a Manuscript
The Scientific World Journal
Volume 2015 (2015), Article ID 291680, 9 pages
http://dx.doi.org/10.1155/2015/291680
Research Article

Using Bioinformatics Approach to Explore the Pharmacological Mechanisms of Multiple Ingredients in Shuang-Huang-Lian

1School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China
2School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, China
3Institute of Basic Research of Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China

Received 5 January 2015; Revised 10 June 2015; Accepted 7 July 2015

Academic Editor: Josiah Poon

Copyright © 2015 Bai-xia Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Li, Z. Q. Zhang, L. J. Wu, X. G. Zhang, Y. D. Li, and Y. Y. Wang, “Understanding ZHENG in traditional Chinese medicine in the context of neuro-endocrine-immune network,” IET Systems Biology, vol. 1, no. 1, pp. 51–60, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. X. Chen, H. Zhou, Y. B. Liu et al., “Database of traditional Chinese medicine and its application to studies of mechanism and to prescription validation,” British Journal of Pharmacology, vol. 149, no. 8, pp. 1092–1103, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. Z. L. Ji, H. Zhou, J. F. Wang, L. Y. Han, C. J. Zheng, and Y. Z. Chen, “Traditional Chinese medicine information database,” Journal of Ethnopharmacology, vol. 103, no. 3, 501 pages, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. J. Ye, X. Song, Z. Liu et al., “Development of an LC-MS method for determination of three active constituents of Shuang-huang-lian injection in rat plasma and its application to the drug interaction study of Shuang-huang-lian freeze-dried powder combined with levofloxacin injection,” Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 898, pp. 130–135, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. H. Liu, Y. X. Qiao, B. Liu, and J. J. Zhou, “Transformation of traditional Chinese medicine database into data warehouse,” Chinese Pharmaceutical Journal, vol. 9, pp. 645–648, 2006. View at Google Scholar
  6. V. Law, C. Knox, Y. Djoumbou et al., “DrugBank 4.0: shedding new light on drug metabolism,” Nucleic Acids Research, vol. 42, no. 1, pp. D1091–D1097, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. D. Croft, A. F. Mundo, R. Haw et al., “The Reactome pathway knowledgebase,” Nucleic Acids Research, vol. 42, no. 1, pp. D472–D477, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. T. S. Keshava Prasad, R. Goel, K. Kandasamy et al., “Human protein reference database—2009 update,” Nucleic Acids Research, vol. 37, no. 1, pp. D767–D772, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. L. Ji, R. L. Ren, H. Gu et al., “dTGS: method for effective components identification from traditional Chinese medicine formula and mechanism analysis,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 840427, 9 pages, 2013. View at Publisher · View at Google Scholar
  10. J. Yan, Y. Wang, S.-J. Luo, and Y.-J. Qiao, “TCM grammar systems: an approach to aid the interpretation of the molecular interactions in Chinese herbal medicine,” Journal of Ethnopharmacology, vol. 137, no. 1, pp. 77–84, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. W. Yun, “Entity grammar systems: a grammatical tool for studying the hierarchal structures of biological systems,” Bulletin of Mathematical Biology, vol. 66, no. 3, pp. 447–471, 2004. View at Publisher · View at Google Scholar · View at MathSciNet · View at Scopus
  12. B. Ruot, I. Papet, F. Béchereau et al., “Increased albumin plasma efflux contributes to hypoalbuminemia only during early phase of sepsis in rats,” The American Journal of Physiology—Regulatory Integrative and Comparative Physiology, vol. 284, no. 3, pp. R707–R713, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. J. U. Hedlund, L.-O. Hansson, and A. B. Ortqvist, “Hypoalbuminemia in hospitalized patients with community-acquired pneumonia,” Archives of Internal Medicine, vol. 155, no. 13, pp. 1438–1442, 1995. View at Publisher · View at Google Scholar · View at Scopus
  14. E. Persson, P. J. Hogg, and J. Stenflo, “Effects of Ca2+ binding on the protease module of factor Xa and its interaction with factor Va: evidence for two Gla-independent Ca2+-binding sites in factor Xa,” The Journal of Biological Chemistry, vol. 268, no. 30, pp. 22531–22539, 1993. View at Google Scholar · View at Scopus
  15. E. A. Norstrøm, S. Tran, M. Steen, and B. Dahlbäck, “Effects of factor Xa and protein S on the individual activated protein C-mediated cleavages of coagulation factor Va,” The Journal of Biological Chemistry, vol. 281, no. 42, pp. 31486–31494, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. W. Zhou, X. X. Zhu, A. L. Yin et al., “Effect of various absorption enhancers based on tight junctions on the intestinal absorption of forsythoside A in Shuang-Huang-Lian, application to its antivirus activity,” Pharmacognosy Magazine, vol. 10, no. 37, pp. 9–17, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. X. Gao, M. Guo, Q. Li et al., “Plasma metabolomic profiling to reveal antipyretic mechanism of Shuang-Huang-Lian injection on yeast-induced pyrexia rats,” PLoS ONE, vol. 9, no. 6, Article ID e100017, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. R. Gao, Y. N. Lin, G. Liang, B. Yu, and Y. Gao, “Comparative pharmacokinetic study of chlorogenic acid after oral administration of lonicerae japonicae flos and shuang-huang-lian in normal and febrile rats,” Phytotherapy Research, vol. 28, no. 1, pp. 144–147, 2014. View at Publisher · View at Google Scholar · View at Scopus
  19. Y. Gao, L. Fang, R. Cai et al., “Shuang-Huang-Lian exerts anti-inflammatory and anti-oxidative activities in lipopolysaccharide-stimulated murine alveolar macrophages,” Phytomedicine, vol. 21, no. 4, pp. 461–469, 2014. View at Publisher · View at Google Scholar · View at Scopus
  20. C. M. Park and Y.-S. Song, “Luteolin and luteolin-7-O-glucoside inhibit lipopolysaccharide-induced inflammatory responses through modulation of NF-κB/Ap-1/PI3K-AKT signaling cascades in RAW 264.7 cells,” Nutrition Research and Practice, vol. 7, no. 6, pp. 423–429, 2013. View at Publisher · View at Google Scholar · View at Scopus
  21. H. Lee, Y. O. Kim, H. Kim et al., “Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia,” The FASEB Journal, vol. 17, no. 13, pp. 1943–1944, 2003. View at Google Scholar
  22. Y.-C. Chen, L.-L. Yang, and T. J.-F. Lee, “Oroxylin A inhibition of lipopolysaccharide-induced iNOS and COX-2 gene expression via suppression of nuclear factor-κB activation,” Biochemical Pharmacology, vol. 59, no. 11, pp. 1445–1457, 2000. View at Publisher · View at Google Scholar · View at Scopus
  23. J. He, X.-P. Hu, Y. Zeng et al., “Advanced research on acteoside for chemistry and bioactivities,” Journal of Asian Natural Products Research, vol. 13, no. 5, pp. 449–464, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. L. An and F. Feng, “Network pharmacology-based antioxidant effect study of Zhi-Zi-da-huang decoction for alcoholic liver disease,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, Article ID 492470, 6 pages, 2015. View at Publisher · View at Google Scholar
  25. F. Zhao, L. Guochun, Y. Yang, L. Shi, L. Xu, and L. Yin, “A network pharmacology approach to determine active ingredients and rationality of herb combinations of Modified-Simiaowan for treatment of gout,” Journal of Ethnopharmacology, vol. 168, pp. 1–16, 2015. View at Publisher · View at Google Scholar