Research Article
Effects of 5-Amyno-4-(1,3-benzothyazol-2-yn)-1-(3-methoxyphenyl)-1,2-dihydro-3H-pyrrol-3-one Intake on Digestive System in a Rat Model of Colon Cancer
Table 4
Parameters of jejunal mucosa for rats treated by D1 and 5FU under DMH-induced carcinogenesis. Mean ± SEM,
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| | | Mucosa thickness, m | Enterocytes height, m | Enterocytes nuclei cross-sectional area, m2 | Goblet cells cross-sectional area, m2 | Mitotic index, % |
| | Control | 636.92 ± 23.15 | 23.20 ± 1.11 | 25.68 ± 1.27 | 112.24 ± 6.48 | 4.40 ± 0.45 |
| | 793.08 ± 53.08 () | 22.00 ± 1.24 | 27.32 ± 1.75 | 102.60 ± 6.97 | 5.22 ± 0.43 |
| | 720.85 ± 39.5 () | 22.13 ± 1.58 | 19.49 ± 1.16 () | 95.63 ± 5.24 () | 6.70 ± 0.65 () |
| | 5FU | 681.01 ± 18.56 () | 26.31 ± 1.03 () | 22.41 ± 1.62 () | 107.11 ± 5.78 | 5.95 ± 0.59 () |
| | DMH | 627.75 ± 20.65 | 23.20 ± 0.90 | 22.45 ± 1.6 () | 106.24 ± 6.36 | 5.38 ± 0.96 |
| | DMH + | 756.73 ± 24.67 (, , ) | 25.60 ± 0.94 (, , ) | 19.05 ± 1.04 (, ) | 100.24 ± 6.73 () | 5.81 ± 0.4 (, ) |
| | DMH + | 800.06 ± 41.61 (, , ) | 26.14 ± 1.22 (, , ) | 21.60 ± 1.29 () | 94.42 ± 6.5 (, ) | 4.53 ± 0.45 |
| | DMH + 5FU | 636.70 ± 35.05 | 23.33 ± 1.30 | 19.09 ± 1.03 (, ) | 97.40 ± 5.62 () | 3.72 ± 0.33 () |
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values indicated in comparison with control; compared to DMH group; compared to DMH + 5FU group: for DMH + and DMH + groups.
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