TY - JOUR
A2 - Danckwerts, Paul
AU - Dave, Vivek
AU - Paliwal, Sarvesh
AU - Yadav, Sachdev
AU - Sharma, Swapnil
PY - 2015
DA - 2015/01/13
TI - Effect of In Vitro Transcorneal Approach of Aceclofenac Eye Drops through Excised Goat, Sheep, and Buffalo Corneas
SP - 432376
VL - 2015
AB - The current study involves the evaluation of factors that influence the transcorneal permeation of aqueous drops of aceclofenac ophthalmic formulation through freshly excised goat, sheep, and buffalo corneas. Aceclofenac formulation with different concentrations 0.1–0.5% (w/v) and with different pH and different preservatives, was taken into account. The amount of drug permeated from different formulations was estimated using an Franz diffusion cell. A linear increase in drug permeation was observed with increase in pH (5.5 to 7.4). The apparent permeability coefficient was found to be maximum 15.01±0.45 on goat cornea and maximum transport of aceclofenac was observed at physiological pH of tears (i.e., 7). The results advocate that aceclofenac 0.5% (w/v) ophthalmic solution (pH 7.0) containing BAK (0.01%) provides maximum in vitro ocular permeability through goat, sheep, and buffalo corneas.
SN - 2356-6140
UR - https://doi.org/10.1155/2015/432376
DO - 10.1155/2015/432376
JF - The Scientific World Journal
PB - Hindawi Publishing Corporation
KW -
ER -