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The Scientific World Journal
Volume 2015 (2015), Article ID 483208, 6 pages
http://dx.doi.org/10.1155/2015/483208
Clinical Study

Radiation-Associated Toxicities in Obese Women with Endometrial Cancer: More Than Just BMI?

1Department of Radiation Oncology, City of Hope, Duarte, CA 91010, USA
2Department of Radiation Oncology, University of Southern California, Los Angeles, CA 90033, USA
3Department of Gynecologic Oncology, Obstetrics-Gynecology, University of Southern California, Los Angeles, CA 90033, USA
4Genentech-Roche, 1 DNA Way, MS 444B, South San Francisco, CA 94080, USA

Received 31 December 2014; Revised 29 April 2015; Accepted 12 May 2015

Academic Editor: Thomas Efferth

Copyright © 2015 Savita V. Dandapani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. The study characterizes the impact of obesity on postoperative radiation-associated toxicities in women with endometrial cancer (EC). Material and Methods. A retrospective study identified 96 women with EC referred to a large urban institution’s radiation oncology practice for postoperative whole pelvic radiotherapy (WPRT) and/or intracavitary vaginal brachytherapy (ICBT). Demographic and clinicopathologic data were obtained. Toxicities were graded according to RTOG Acute Radiation Morbidity Scoring Criteria. Follow-up period ranged from 1 month to 11 years (median 2 years). Data were analyzed by χ2, logistic regression, and recursive partitioning analyses. Results. 68 EC patients who received WPRT and/or ICBT were analyzed. Median age was 52 years (29–73). The majority were Hispanic (71%). Median BMI at diagnosis was 34.5 kg/m2 (20.5–56.6 kg/m2). BMI was independently associated with radiation-related cutaneous () and gynecologic-related () toxicities. Younger women also reported more gynecologic-related toxicities (). Adjuvant radiation technique was associated with increased gastrointestinal- and genitourinary-related toxicities but not gynecologic-related toxicity. Conclusions. Increasing BMI was associated with increased frequency of gynecologic and cutaneous radiation-associated toxicities. Additional studies to critically evaluate the radiation treatment dosing and treatment fields in obese EC patients are warranted to identify strategies to mitigate the radiation-associated toxicities in these women.