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The Scientific World Journal
Volume 2015 (2015), Article ID 495271, 7 pages
Research Article

Formulation and Evaluation of Galantamine Gel as Drug Reservoir in Transdermal Patch Delivery System

1Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43300 Serdang, Selangor, Malaysia
2Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43300 Serdang, Selangor, Malaysia

Received 8 October 2014; Revised 15 January 2015; Accepted 4 February 2015

Academic Editor: Herbert Budka

Copyright © 2015 Woo Fong Yen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Figure S1 shows the standard calibration curve for galantamine hydrobromide. The curve was plotted in concentration range from 100 ppm to 1000 ppm, with line equation (y = 884.86x - 16100) and correlation coeffiecient (R2 = 0.9956).

Figure S2 shows the HPLC spectrum for galantamine hydrobromide with concentration of 100 ppm. The peak retention time is 1.146 mins and area under peak is 79859 μV*sec.

Figure S3 shows the graphical abstract for this work. The drug release studies were carried out by using Franz Diffusion Cell with three parts, namely donor compartment, barrier and receptor compartment. Donor compartment was filled with galantamine hydrobromide-loaded gel and receptor compartment was filled with phosphate buffer solution. Cellulose acetate membrane was used as the barrier between donor and receptor compartment. The release of galantamine hydrobromide from gel into receptor compartment was analyzed quantitavely by using HPLC.

  1. Supplementary Materials