Ultrastructural Changes in Clinical and Microbiota Isolates of Klebsiella pneumoniae Carriers of Genes bla_SHV, bla_TEM, bla_CTX-M, or bla_KPC When Subject to β-Lactam Antibiotics

Table 1

MICs of K. pneumoniae isolates obtained in hospital and sub-MICs used for analysis by electron microscopy.

Isolates	Cefotaxime			Ceftazidime			Aztreonam
	(μg mL^−1)			(μg mL^−1)			(μg mL^−1)
ESBL	MICs	Sub-MICs		MICs	Sub-MICs		MICs	Sub-MICs
		TEM	SEM		TEM	SEM		TEM	SEM
K3C	>256	64; 32	32	128	32; 16	32	64	32; 16	32
K16R	>256	64; 32	32	32	16; 8	16	16	4	4
Isolates	Cefotaxime			Ceftazidime			Imipenem
	(μg mL^−1)			(μg mL^−1)			(μg mL^−1)
KPC	MICs	Sub-MICs		MICs	Sub-MICs		MICs	Sub-MICs
		TEM	SEM		TEM	SEM		TEM	SEM
K652	≥256	98	98	≥256	27	27	≥128	16	16

MICs: minimum inhibitory concentrations; sub-MICs: sub-minimum inhibitory concentrations; TEM: transmission electron microscopy; and SEM: scanning electron microscopy.