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The Scientific World Journal
Volume 2015, Article ID 676719, 33 pages
http://dx.doi.org/10.1155/2015/676719
Review Article

Radiotracers Used for the Scintigraphic Detection of Infection and Inflammation

RAH Radiopharmacy, Nuclear Medicine Department, Royal Adelaide Hospital, Adelaide, SA 5000, Australia

Received 28 July 2014; Revised 16 October 2014; Accepted 20 October 2014

Academic Editor: Harry Hendrikse

Copyright © 2015 Chris Tsopelas. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Over the last forty years, a small group of commercial radiopharmaceuticals have found their way into routine medical use, for the diagnostic imaging of patients with infection or inflammation. These molecular radiotracers usually participate in the immune response to an antigen, by tagging leukocytes or other molecules/cells that are endogenous to the process. Currently there is an advancing effort by researchers in the preclinical domain to design and develop new agents for this application. This review discusses radiopharmaceuticals used in the nuclear medicine clinic today, as well as those potential radiotracers that exploit an organism’s defence mechanisms to an infectious or inflammatory event.