Table of Contents Author Guidelines Submit a Manuscript
The Scientific World Journal
Volume 2015, Article ID 728278, 8 pages
http://dx.doi.org/10.1155/2015/728278
Research Article

Bone Morphology in 46 BXD Recombinant Inbred Strains and Femur-Tibia Correlation

1Department of Orthopaedic Surgery and Biomedical Engineering, Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN 38163, USA
2Department of Medicine-Nephrology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
3Division of Nephrology, Northwestern University, Chicago, IL 60208, USA
4Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
5Department of Biomedical Engineering, University of Memphis, Memphis, TN 38152, USA
6Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38163, USA

Received 26 August 2014; Revised 24 December 2014; Accepted 29 December 2014

Academic Editor: Tianhua Niu

Copyright © 2015 Yueying Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We examined the bone properties of BXD recombinant inbred (RI) mice by analyzing femur and tibia and compared their phenotypes of different compartments. 46 BXD RI mouse strains were analyzed including progenitor C57BL/6J () and DBA/2J () and two first filial generations (D2B6F1 and B6D2F1). Strain differences were observed in bone quality and structural properties () in each bone profile (whole bone, cortical bone, or trabecular bone). It is well known that skeletal phenotypes are largely affected by genetic determinants and genders, such as bone mineral density (BMD). While genetics and gender appear expectedly as the major determinants of bone mass and structure, significant correlations were also observed between femur and tibia. More importantly, positive and negative femur-tibia associations indicated that genetic makeup had an influence on skeletal integrity. We conclude that (a) femur-tibia association in bone morphological properties significantly varies from strain to strain, which may be caused by genetic differences among strains, and (b) strainwise variations were seen in bone mass, bone morphology, and bone microarchitecture along with bone structural property.