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The Scientific World Journal
Volume 2015, Article ID 803752, 8 pages
Review Article

Pruritus in Systemic Diseases: A Review of Etiological Factors and New Treatment Modalities

Department of Dermatology, Okmeydanı Training and Research Hospital, 34384 Istanbul, Turkey

Received 20 February 2015; Revised 11 June 2015; Accepted 16 June 2015

Academic Editor: Uwe Wollina

Copyright © 2015 Nagihan Tarikci et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Pruritus is the most frequently described symptom in dermatology and can significantly impair the patient’s quality of life. In 10–50% of adults with persistent pruritus, it can be an important dermatologic clue for the presence of a significant underlying systemic disease such as renal insufficiency, cholestasis, hematologic disorder, or malignancy (Etter and Myers, 2002; Zirwas and Seraly, 2001). This review describes the presence of pruritus in different systemic diseases. It is quite important to discover the cause of pruritus for providing relief for the patients experiencing substantial morbidity caused by this condition.