Multivariate Statistical Analysis as a Supplementary Tool for Interpretation of Variations in Salivary Cortisol Level in Women with Major Depressive Disorder
Table 1
Average levels of cortisol in saliva of patients under antidepressant therapy.
Antidepressant
Active substance (dose, mg/day)
Monotherapy
Polypragmasy
Number of patients
Mean concentration of salivary cortisol, ng/mL
Number of patients
Mean concentration of salivary cortisol, ng/mL
Initial
Final
Highest
Lowest
Initial
Final
Highest
Lowest
TCAs
Amitriptyline (100 mg)
7
53.03
18.84
161.25
1.25
—
Clomipramine (100 mg)
3
16.46
13.08
55.00
2.50
1
72.00
5.50
72.00
2.62
Opipramol (100 mg)
1
33.75
13.75
33.75
2.50
—
Doxepin (100 mg)
1
87.72
5.62
87.72
1.62
1
13.50
2.00
13.50
2.00
SSRIs
Sertraline (50 mg)
10
39.44
32.51
190.00
0.25
5
39.60
5.10
95.00
1.25
Citalopram (40 mg)
7
59.46
6.89
93.25
0.62
3
52.42
8.42
72.00
1.75
Escitalopram (20 mg)
5
47.46
4.77
98.50
1.25
4
39.45
5.06
61.00
1.25
Fluvoxamine (100 mg)
3
43.54
20.75
49.75
2.50
—
Fluoxetine (20 mg)
1
2.50
3.75
3.75
2.50
—
Paroxetine (20 mg)
2
68.25
98.94
195.00
2.50
—
SNRIs
Venlafaxine (75 mg)
14
88.32
9.13
372.5
0.25
5
41.55
5.45
95.00
2.50
SSAs
Mianserin (90 mg)
7
63.75
26.05
195.00
1.25
5
33.27
6.90
46.25
1.25
NaSSAs
Mirtazapine (45 mg)
1
33.00
8.62
33.00
6.25
1
31.25
2.75
31.25
2.50
SARIs
Trazodone (300 mg)
3
79.17
6.46
182.50
1.25
8
32.91
4.03
45.75
1.50
SSREs
Tianeptine (37.5 mg)
3
40.50
16.62
52.00
1.75
—
RIMA
Moclobemid (600 mg)
1
37.50
5.62
37.50
1.25
—
Others psychoactive drugs
10
44.51
12.22
133.50
1.25
1
42.50
25.00
42.50
2.50
TCAs: tricyclic antidepressants, SSRIs: selective serotonin reuptake inhibitors, SNRIs: serotonin-noradrenalin reuptake inhibitors, SSAs: specific serotonin antidepressants, NaSSAs: noradrenergic and selective serotoninergic antidepressants, SARIs: serotonin antagonist and reuptake inhibitors, SSREs: selective serotonin reuptake enhancers, and RIMA: reversible inhibitors of monoaminooxidase-A.
