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The Scientific World Journal
Volume 2016, Article ID 2695718, 7 pages
Research Article

Excretory Function of Intestinal Tract Enhanced in Kidney Impaired Rats Caused by Adenine

1Kunming Key Laboratory of Molecular Biology for Sinomedicine, Faculty of Basic Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China
2School of Basic Medicine, Kunming Medical University, Kunming 650500, China

Received 16 August 2016; Accepted 26 October 2016

Academic Editor: Eiji Ishimura

Copyright © 2016 Yu Yun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The main aim of the study was to prove the compensative effect of intestine for renal function. Rat kidney was impaired by intragastrically administrating adenine (400 mg per day for 5 days). Intestinal tract was harvested and equally divided into 20 segments except cecum. Kidneys were harvested and histologically examined with hematoxylin-eosin staining kits. Uric acid, urea (BUN), and creatinine in serum were determined with assay kits, and BUN and creatinine in every intestinal segment were also determined. The results showed that adenine was able to increase uric acid level in serum from μg/mL to μg/mL and cause renal function damage with BUN (from  mM to 12. mM) and creatinine (from μM to μM) increasing in serum and with abnormally micromorphological changes in kidney. The amount of BUN and creatinine distributed in intestinal tract was positively correlated with those in blood. In impaired renal function rats, the amount of BUN (from μMole to 10.μMole) and creatinine (from nMole to nMole) distributed in intestinal tract significantly increased. All the results proved that intestinal tract had excretory function compensative for renal function.