Table of Contents Author Guidelines Submit a Manuscript
The Scientific World Journal
Volume 2016 (2016), Article ID 3694901, 7 pages
http://dx.doi.org/10.1155/2016/3694901
Research Article

Origanum majorana Essential Oil Lacks Mutagenic Activity in the Salmonella/Microsome and Micronucleus Assays

1Programa de Pós-Graduação em Ciências Veterinárias, UFRGS, Porto Alegre, RS, Brazil
2Laboratório de Produtos Naturais/Fitoquímica-Farmacologia e Toxicologia Veterinária, Departamento de Farmacologia, UFRGS, Porto Alegre, RS, Brazil
3Laboratório de Farmacognosia e Controle de Qualidade de Fitomedicamentos, Faculdade de Farmácia, UFRGS, Porto Alegre, RS, Brazil
4Laboratório de Reparação de DNA em Eucariotos, Departamento de Biofísica/Centro de Biotecnologia, UFRGS, Porto Alegre, RS, Brazil
5Programa de Pós-Graduação em Farmacologia e Terapêutica, UFRGS, Porto Alegre, RS, Brazil

Received 11 July 2016; Accepted 9 October 2016

Academic Editor: Mugimane Manjanatha

Copyright © 2016 Andrea dos Santos Dantas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. M. Abdel-Massih and A. Abraham, “Extracts of Rosmarinus officinalis, Rheum rhaponticum, and Origanum majorana exhibit significant anti-staphylococcal activity,” International Journal of Pharmaceutical Sciences and Research, vol. 5, pp. 819–828, 2014. View at Google Scholar
  2. I. M. El-Ashmawy, A. Saleh, and O. M. Salama, “Effects of marjoram volatile oil and grape seed extract on ethanol toxicity in male rats,” Basic and Clinical Pharmacology and Toxicology, vol. 101, no. 5, pp. 320–327, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. G. Ramadan, N. M. El-Beih, and M. M. Zahra, “Egyptian sweet marjoram leaves protect against genotoxicity, immunosuppression and other complications induced by cyclophosphamide in albino rats,” British Journal of Nutrition, vol. 108, no. 6, pp. 1059–1068, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. C. Busatta, R. S. Vidal, A. S. Popiolski et al., “Application of Origanum majorana L. essential oil as an antimicrobial agent in sausage,” Food Microbiology, vol. 25, no. 1, pp. 207–211, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. B. Prakash, P. Singh, A. Kedia, and N. K. Dubey, “Assessment of some essential oils as food preservatives based on antifungal, antiaflatoxin, antioxidant activities and in vivo efficacy in food system,” Food Research International, vol. 49, no. 1, pp. 201–208, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. W. Jin Jun, B. Kyung Han, K. Won Yu et al., “Antioxidant effects of Origanum majorana L. on superoxide anion radicals,” Food Chemistry, vol. 75, no. 4, pp. 439–444, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Alizadeh, M. Khosh-Khui, K. Javidnia, O. Firuzi, and S. M. Jokar, “Chemical composition of the essential oil, total phenolic content and antioxidant activity in Origanum majorana L. (Lamiaceae) cultivated in Iran,” Advances in Environmental Biology, vol. 5, no. 8, pp. 2326–2331, 2011. View at Google Scholar · View at Scopus
  8. M. H. H. Roby, M. A. Sarhan, K. A.-H. Selim, and K. I. Khalel, “Evaluation of antioxidant activity, total phenols and phenolic compounds in thyme (Thymus vulgaris L.), sage (Salvia officinalis L.), and marjoram (Origanum majorana L.) extracts,” Industrial Crops and Products, vol. 43, no. 1, pp. 827–831, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Rezaie, B. Jafari, G. Mousavi et al., “Comparative study of sedative, pre-anesthetic and anti-anxiety effect of Origanum majorana extract with diazepam on rats,” Research Journal of Biological Sciences, vol. 6, pp. 611–614, 2011. View at Publisher · View at Google Scholar
  10. Y. Al Dhaheri, S. Attoub, K. Arafat et al., “Anti-metastatic and anti-tumor growth effects of Origanum majorana on highly metastatic human breast cancer cells: inhibition of NFκB signaling and reduction of nitric oxide production,” PLoS ONE, vol. 8, no. 7, Article ID e68808, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Rao, B. Timsina, and V. K. Nadumane, “Evaluation of the anticancer potentials of Origanum marjorana on fibrosarcoma (HT-1080) cell line,” Asian Pacific Journal of Tropical Disease, vol. 4, no. 1, pp. S389–S394, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. J. A. Khan, J. A. Jalal, C. Ioanndes, and S. S. Moselhy, “Impact of aqueous doash extract on urinary mutagenicity in rats exposed to heterocyclic amines,” Toxicology and Industrial Health, vol. 29, no. 2, pp. 142–148, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. E. Vági, B. Simándi, Á. Suhajda, and É. Héthelyi, “Essential oil composition and antimicrobial activity of Origanum majorana L. extracts obtained with ethyl alcohol and supercritical carbon dioxide,” Food Research International, vol. 38, no. 1, pp. 51–57, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. D. Kirkland, L. Reeve, D. Gatehouse, and P. Vanparys, “A core in vitro genotoxicity battery comprising the Ames test plus the in vitro micronucleus test is sufficient to detect rodent carcinogens and in vivo genotoxins,” Mutation Research, vol. 721, no. 1, pp. 27–73, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. ICH S2 (R1), Guidance on Genotoxicity Testing and Data Interpretation for Pharmaceuticals Intended for Human Use, 2011.
  16. R. P. Limberger, M. Sobral, A. T. Henriques, C. Menut, and J.-M. Bessière, “Óleos voláteis de espécies de Myrcia nativas do Rio Grande do Sul,” Química Nova, vol. 27, pp. 916–919, 2004. View at Google Scholar
  17. C. A. Simões-Pires, S. Debenedetti, E. Spegazzini et al., “Investigation of the essential oil from eight species of Baccharis belonging to sect. Caulopterae (Asteraceae, Astereae): a taxonomic approach,” Plant Systematics and Evolution, vol. 253, no. 1–4, pp. 23–32, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. R. P. Adams, Identification of Essential Oil Components by Gas Chromatograph/Quadrupole Mass Spectrometry, Allured Publishing, Carol Stream, Ill, USA, 2007.
  19. D. M. Maron and B. N. Ames, “Revised methods for the Salmonella mutagenicity test,” Mutation Research/Environmental Mutagenesis and Related Subjects, vol. 113, no. 3-4, pp. 173–215, 1983. View at Publisher · View at Google Scholar · View at Scopus
  20. M. O. Bradley, B. Bhuyan, M. C. Francis, R. Langenbach, A. Peterson, and E. Huberman, “Mutagenesis by chemical agents in V79 Chinese hamster cells: a review and analysis of the literature. A report of the gene-tox program,” Mutation Research/Reviews in Genetic Toxicology, vol. 87, no. 2, pp. 81–142, 1981. View at Publisher · View at Google Scholar · View at Scopus
  21. OECD, “Test no. 487: in vitro mammalian cell micronucleus test, OECD guidelines for the testing of chemicals, section 4,” Health Effects, 26 pages, 2014. View at Publisher · View at Google Scholar
  22. T. S. Gonçalves, L. M. D. Menezes, C. Trindade et al., “Cytotoxicity and genotoxicity of orthodontic bands with or without silver soldered joints,” Mutation Research—Genetic Toxicology and Environmental Mutagenesis, vol. 762, pp. 1–8, 2014. View at Publisher · View at Google Scholar · View at Scopus
  23. I. Decordier, A. Papine, K. Vande Loock, G. Plas, F. Soussaline, and M. Kirsch-Volders, “Automated image analysis of micronuclei by IMSTAR for biomonitoring,” Mutagenesis, vol. 26, no. 1, pp. 163–168, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. N. Jelali, W. Dhifi, T. Chahed, and B. Marzouk, “Salinity effects on growth, essential oil yield and composition and phenolic compounds content of marjoram (origanum majorana l.) leaves,” Journal of Food Biochemistry, vol. 35, no. 5, pp. 1443–1450, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Ramos, L. B. Rojas, M. E. Lucena, G. Meccia, and A. Usubillaga, “Chemical composition and antibacterial activity of Origanum majorana L. essential oil from the Venezuelan Andes,” Journal of Essential Oil Research, vol. 23, no. 5, pp. 45–49, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. B. Ncube, J. F. Finnie, and J. Van Staden, “Quality from the field: the impact of environmental factors as quality determinants in medicinal plants,” South African Journal of Botany, vol. 82, pp. 11–20, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. M. R. A. Rodrigues, E. B. Caramão, L. Arce, A. Ríos, and M. Valcárcel, “Determination of monoterpene hydrocarbons and alcohols in Majorana hortensis Moench by micellar electrokinetic capillary chromatographic,” Journal of Agricultural and Food Chemistry, vol. 50, no. 15, pp. 4215–4220, 2002. View at Publisher · View at Google Scholar · View at Scopus
  28. OECD, “Test No. 471: bacterial reverse mutation test, OECD guidelines for the testing of chemicals, section 4: health effects,” OECD 471, OECD Publishing, 1997. View at Publisher · View at Google Scholar
  29. M. Fenech, M. Kirsch-Volders, A. T. Natarajan et al., “Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells,” Mutagenesis, vol. 26, no. 1, pp. 125–132, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. A. Calcabrini, A. Stringaro, L. Toccacieli et al., “Terpinen-4-ol, the main component of Melaleuca alternifolia (Tea Tree) oil inhibits the in vitro growth of human melanoma cells,” The Journal of Investigative Dermatology, vol. 122, no. 2, pp. 349–360, 2004. View at Publisher · View at Google Scholar · View at Scopus
  31. M. R. Gomes-Carneiro, M. E. S. Viana, I. Felzenszwalb, and F. J. R. Paumgartten, “Evaluation of β-myrcene, α-terpinene and (+)- and (−)-α-pinene in the Salmonella/microsome assay,” Food and Chemical Toxicology, vol. 43, no. 2, pp. 247–252, 2005. View at Publisher · View at Google Scholar · View at Scopus