In Vitro Antifungal Activity of Hexahydropyrimidine Derivatives against the Causative Agents of Dermatomycosis

Figure 4

Electron micrographs of T. rubrum CCT 5507 URM 1666 exposed or not to the reference drugs and hexahydropyrimidine derivative of interest. (a) T. rubrum CCT 5507 URM 1666 not subjected to pharmacological treatment; (b) T. rubrum CCT 5507 URM 1666 subjected to treatment with terbinafine; (c) T. rubrum CCT 5507 URM 1666 subjected to treatment with ketoconazole; (d) T. rubrum CCT 5507 URM 1666 subjected to treatment with HHP1; (e) T. rubrum CCT 5507 URM 1666 subjected to treatment with HHP3; (f) T. rubrum CCT 5507 URM 1666 subjected to treatment with HHP4. (I) Wrinkled hyphae. (II) crushed hyphae. (III) microconidia. (IV) hyphal breaks. (V) loss of hyphae intracellular content.

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