Research Article

Antibacterial and Antibiotic-Potentiating Activities of Thirteen Cameroonian Edible Plants against Gram-Negative Resistant Phenotypes

Table 7

Antibiotic resistance modulatory activity of broad bean extract of Theobroma cacao.

AntibioticsExtract concentrationBacteria MIC (g/mL) and modulating factors (in bracket)
E. coliE. aerogenesK. pneumoniaeP. stuartiiP. aeruginosaModulating effect (%)
AG102AG100AtetEA27EA289KP55KP63PS2636NEA16PA01PA124

CHL6486464646432646432
CMI/232 (2)8 (1)32 (2)128 (0.5)128 (0.5)16 (4)8 (4)16 (4)64 (1)32 (1)50.00
CMI/432 (2)8 (1)32 (2)128 (0.5)128 (0.5)64 (1)8 (4)16 (4)64 (1)32 (1)40.00
KAN0324163264648321664
CMI/216 (2)4 (1)8 (2)64 (1)64 (1)64 (1)2 (4)8 (4)16 (1)32 (2)50.00
CMI/416 (2)4 (1)8 (2)64 (1)64 (1)64 (1)4 (2)16 (2)16 (1)32 (2)50.00
STP01282562566464256>2561625664
CMI/2128 (1)- (na)256 (1)64 (1)32(2)128(2)32(<8)16 (1)256 (1)32 (2)40.00
CMI/4128 (1)- (na)256 (1)128(2)32(2)256(1)16(<16)16(1)256 (1)32 (2)40.00
CIP081118142216
CMI/24 (2)1(1)1 (1)0.5 (2)16 (0.5)0.5 (2)<0.5(<8)2 (1)0.5 (4)8(2)60.00
CMI/44 (2)1(1)2 (1)1(1)16 (0.5)0.5 (2)<0.5(<8)4 (0.5)1 (2)8(2)40.00
TET08< 0.5643216324321616
CMI/28(1)< 0.5 (na)64 (1)16 (2)16 (2)8(4)0.5 (8)4 (8)8 (2)8(2)70.00
CMI/48(1)< 0.5 (na)64 (1)32 (1)16(1)16 (2)0.5 (8)4 (8)4 (4)8(2)50.00
ERY06481664643216321632
CMI/232 (2)8 (1)8 (2)128 (0.5)16 (4)8 (4)16 (1)4 (8)16 (1)16 (2)60.00
CMI/432 (2)8 (1)16 (1)128 (0.5)32(2)16 (2)16 (1)16 (2)16 (1)16 (2)50.00

CHL: chloramphenicol, KAN: kanamycin, STP: streptomycin, CIP: ciprofloxacin, TET: tetracycline, ERY: erythromycin; −: MIC not detected at up to 256 μg/mL; ( ): modulating factor; MIC: minimal inhibitory concentration; values in bold represent modulating factor ≥ 2.