|
| Reference | Animal | Experiment | Study groups | Intervention | Duration of the experiment | Results |
|
| [21] | Albino male rats (Wistar) | Mucosal ulceration left by abrasion with scalpel blade and marker of 8 mm diameter | Group 1. Treated with saline
Group 2. Treated with chamomile extract
Group 3. Treated with triamcinolone | NC | 10 days | Epithelium refurbished absence of inflammation
↑ collagen deposition
↓ apoptosis and TNF-α |
|
| [22] | Albino male rats (Wistar) | Injury with 1 mm of depth in the central region of the tongue | Group 1. Chamomile ointment
Group 2. Without treatment | Topical application of 2 ml chamomile extract with concentration of 10% | 10 days | ↑ epithelialization and collagenous fibers
↑ fibroblasts
↓ inflammation |
|
| [23] | Female albino rats (Wistar) | Intraperitoneal administration of 5-Fluorouracil | Group 1. Distilled water management
Group 2. Chamomile extract | Probe intragastric administration of the alcoholic extract of chamomile | 12 days | ↓ toxicity caused by medicine
↓ size of the lesion prolonged use caused toxicity in the mucosa of the tongue |
|
| [24] | Female albino mice (Swiss) | Application of injection of carrageenan on hind right mouse | Group 1. Saline
Group 2. Chamomile | MeOH extract of chamomile | 16 days | ↓ development of arthritis
↓ histamine
↓ inflammation |
|
| [25] | Albino male rats (Wistar) | The animals were trichotomized with an electric razor in an area of skin back approximately 10 cm | Group 1. Ethanolic extract of Chamomile
Group 2. Crude extract of Chamomile | Topical application in skin of Wistar rats with carrageenan-induced paw edema | 12 days | Not provide anti-inflammatory action on the induced edema |
|
| [9] | Male Golden Syrian hamsters | Intraperitoneal administration of 5-Fluorouracil | Group 1. Without treatment
Group 2. Chamomile
Group 3. Corticosteroids | Ointment with 100 g of chamomile extract | 14 days | ↑ levels of TNF-α on the 5th day
↓ severity
↓ levels of IL-1β and TNF-α |
|
| [26] | Female Syrian Golden hamsters | Intraperitoneal administration of 5-Fluorouracil | Group 1. Without treatment
Group 2. Chamomile
Group 3. Corticosteroids | Ointment with 100 g of chamomile extract | 16 days | ↓ incidence of oral mucositis
↓ severity
↓ vascular hyperemia
↓ inflammatory infiltration |
|
| [27] | Albino male rats (Wistar) | Intraperitoneal administration of 5-Fluorouracil | Group 1. Without treatment
Group 2. Chamomile | Ointment with 10% of chamomile extract | 10 days | ↑ reepithelialization
↑ collagen fibers
↓ of the inflammatory process
↓ on wound size |
|
| [28] | Albino male rats (Wistar) | Traumatic ulcers on tongue with 3 mm diameter | Group 1. Without drugs
Group 2. Chamomile
Group 3. Acetone of triamcinolone topical | Topical formulation of Chamomile | 14 days | ↑ healing
↑ repair of the epithelium and connective tissue total in 5 days
↓ inflammatory cells |
|
| [29] | Albino male rats (Wistar) | Immersion in boiling water for 8 seconds, resulting in burning of 20% of the body area | Group 1. Without treatment
Group 2. Application of olive oil
Group 3. Chamomile | Chamomile flowers folder added to olive oil | 67 days | ↑ tissue regeneration
↓ inflammatory infiltration |
|
