Control of Cryptococcus Gattii Biofilms by an Ethanolic Extract of Cochlospermum Regium (Schrank) Pilger Leaves

Table 1

Antifungal activity of extract of C. regium, alone and in combination with fluconazole, against planktonic Cryptococcus gattii cells.

Cryptococcus gattii	Source	MIC ECR; (μg/mL)		MIC Fluconazole; (μg/mL)		FICI	Interpretation
		Alone	Combination	Alone	Combination
32G	CSF	62.5	31.25	2	1	1	Indifferent
476	Sputum	125	31.25	8	8	1.25	Indifferent
2164	Sputum	125	62.5	2	1	1	Indifferent
ATCC 56990	Sputum	250	125	4	2	1	Indifferent

ECR: ethanolic extract from leaves of Cochlospermum regium; MIC: minimum inhibitory concentration; FICI: fractional inhibitory concentration index; CSF: cerebrospinal fluid.