Mechanical Transformation of Compounds Leading to Physical, Chemical, and Biological Changes in Pharmaceutical Substances

Figure 1

Particle size distribution (optical microscopy 1,2; 4,5 and laser diffraction 3,6) of native (1-3) and dispersed (4-6) lactose monohydrate powders (SuperTab 30G). Granulometric analysis of the lactose monohydrate suspension by laser diffraction method (volume distribution, measurement interval from 1 to 120 μm) was carried out immediately after applying 0.6 g of the substance into 3 ml of water (n ≥ 3, р < 0.05).