Review Article

The Effect of Genetically Modified Food on Infertility Indices: A Systematic Review Study

Table 1

Characteristics of the studies on the effects of genetically modified crops on animal’s fertility.

No.AuthorYearSample sizeAnimalGenerationDurationProduct% of GM cropsOutcome

1Gyu Seek Rhee200525 in each group and in each generation (total: male 75, female 75)Sprague Dawley rats510 weeksPotato5%Fertility index, mating index, gestation index (%), gestation length, delivery index (%), litter size, estrous cycle
2Sishuo Cao201012 mice for each group (6 males and 6 females per treatment)Mice15 daysRice: PET-30a(+)-Cry1C-rcp-BL21 (DE3)5 g (Cry1C protein)/kgSperm abnormality
3Wang201324Wistar rats190 daysRice TT5160%Sperm motility, sperm morphology, sperm head counts
4Zhou201460Sprague Dawley rats313 weeksRice70%Sperm morphology, sperm head counts, copulation index (%), fertility index (%), gestation length (days), live-birth rate, no. of pups, birth, gender ratio of pups, estrous cycle (days), sperm parameters
5Tyshko2014380 adult animals and 1540 pupsWistar rats390 daysMaize32–33%Fertility index, number of alive fetuses, total number of pups, mean litter size, ratio ♂/♀ in the litter
6Guo201530Male Wistar rats190 days, 13 weeksMaize BT79984.7%,Sperm motility, sperm morphology, sperm head counts
7Wang Er Hui201615 males/30 females, each group; 8 male offspring ratsWistar rats270 daysRice TT5160%Sperm motility, sperm morphology, sperm head counts, testicular function enzyme ACP, LDH, and SDH activity

ACP, acid phosphatase; GM, genetically modified; LDH, lactic dehydrogenase; SDH, succinate dehydrogenase.