The Effect of Genetically Modified Food on Infertility Indices: A Systematic Review Study

Table 2

Effects of the genetically modified crops on animal’s fertility (based on sperm head count, sperm motility, sperm abnormality, and fertility index).

No.

Author

Year

Sperm head (1000000/Ml)

Sperm mortality%

Sperm abnormality%

Fertility index^a

Clinical pathological parameter

GM

Non-GM

Standard

GM

Non-GM

Standard

GM

Non-GM

Standard

GM

Non-GM

Standard

1

Gyu Seek Rhee

2005

—

—

—

80–100%

80 to 100%

80 to 100%

—

—

—

72–100%

88–100%

92–100%

No adverse effects on the multigeneration reproductive-developmental ability. Nonmotile sperms showed 0%.

2

Sishuo Cao

2010

—

—

—

—

—

—

Cry1C.DOSE.1250 = . 1.50 ± 0.5. Cry1C.DOSE.625 = 1.24 ± 0.6. Cry1C.DOSE.125 = 1.38 ± 0.4

Positive control = 4.86 ± 1.2

Negative control = 1.28 ± 0.5

—

—

—

<16 sperm abnormalities per 1000 cells; No adverse effect

3

Wang

2013

160.59 ± 34.91

164.17 ± 19.33

157.45 ± 24.51

82.94 ± 10.28

85.56 ± 8.23

86.37 ± 8.57

9.13 ± 1.90

10.25 ± 2.38

8.88 ± 1.36

—

—

—

No significant differences were detected in terms of sperm motility; sperm head counts and morphology of epididymis sperm between groups

4

Zhou

2014

5.66 ± 1.83

5.51 ± 1.74

5.48 ± 1.49

—

—

—

1.52 ± 0.34

1.53 ± 0.28

1.60 ± 0.21

85%

85–90%

85–90%

Some statistically significant differences were observed in rats consuming the high amylose rice, differences were generally of small magnitude, herefore not considered to be biologically meaningful or treatment related.

5

Tyshko

2014

—

—

—

—

—

—

—

—

—

71–80%

79–92%

—

Lack of any reproductive toxicity

6

Guo

2015

32.35 ± 1.79

30.50 ± 2.62

31.69 ± 2.33

87.84 ± 4.00

83.91 ± 6.02

84.06 ± 5.90

9.44 ± 0.98

9.00 ± 0.93

9.00 ± 0.69

—

—

—

No significant differences in sperm parameters with the diets containing transgenic BT799, Zhen58 and the control, no treatment-related side effects on the reproductive system of male rats.

7

Wang Er Hui

2016

185.49 ± 20.35

173.81 ± 16.49

185.15 ± 27.89

86.02 ± 8.72

83.10 ± 7.05

85.29 ± 10.27

6.38 ± 2.11

6.63 ± 1.93

6.25 ± 2.11

—

—

—

No significant differences on the reproductive system of male offspring rats compared with MingHui63

GM, genetically modified. Significant from control () in F0 group but not in F1, F2, F3, and F4. ^aFertility index (%) = (no. of females pregnant/no. paired) × 100 (ranges from different generations).