|
| Authors (year) | No. of subjects (teeth) | Animal species | Intracanal medications | Scaffolds | Pulpal space/barrier used | Follow-up duration | Root maturation stage (Cvek’s classification) | Main outcomes |
|
| Bakhtiar et al. [32] (2017) | (n = 32) | Dogs | Ciprofloxacin + metronidazole + cefaclor | Treated dentine matrix (TDM) + tricalcium phosphate (TCP) | MTA | 1 years | Stage V (closed apical foramen and completed root development) | Root development/Apical closure |
| Altaii et al. [33] (2017) | (n = 4) | Sheep | TAP | Blood clot | MTA | 6 months | Stage V (closed apical foramen and completed root development) | Root development/Apical closure |
| Saoud et al. [34] (2015) | (n = 16) | Dogs | TAP | Blood clot | MTA | 3 months | Not reported | Not reported in regards to the root development and apical closure, but there are significant results of thickening of the dentinal walls and periapical healing |
| Torabinejad et al. [36] (2015) | (n = 24) | Ferrets | TAP | Blood clot/Gelfoam + PRP + empty negative control | MTA | 3 months | Stage IV (wide opening apical foramen and nearly completed root length) | Significantly more apical narrowing and hard tissue deposition in two scaffold groups compared with not using a scaffold |
| Londero Cde et al. [37] (2015) | (n = 30) | Dogs | TAP | Blood clot + blood clot with gelfoam + empty negative control | MTA | 7 months | Stage V (closed apical foramen and completed root development) | Apical root development |
| Rodríguez-Benítez et al. [38] (2015) | (n = 40) | Dogs | Modified triantibiotic paste (mTAP) | Blood clot + PRP | Not report | 6 months | Stage V (closed apical foramen and completed root development) | Root thickening/Apical closure |
| Khademi et al. [41] (2014) | (n = 36) | Dogs | TAP | Blood clot | MTA | 3–6 months | Stage V (closed apical foramen and completed root development) | Apical closure, dentinal wall thickening, and periapical healing |
| Yoo et al. [42] (2014) | (n = 30) | Dogs | No report | Blood clot | MTA | 12 weeks | Stage V (closed apical foramen and completed root development) | Apical closure and dentinal wall thickening |
| Zhang et al. [43] (2014) | (n = 27) | Dogs | TAP | Blood clot + PRP | MTA | 3 months | Stage V (closed apical foramen and completed root development) | Apical closure and root wall thickening |
| Tawfik et al. [48] (2013) | (n = 108) | Dogs | TAP | Blood clot + blood clot with bFGF + empty negative control | MTA | 1 week, 3 weeks, and 3 months | Stage I (<1/2 root length with open apex) | Negative results in this study. Root lengthening/thickness did not change. |
| Zhu et al. [49] (2013) | (n = 56) | Dogs | TAP | Blood clot + blood clot with DPCs + PRP + PRP with DPCs | MTA | 3 months | Stage II (1/2 root length with open apex) | Root thickening only, and does not report about the apical closure |
| Petrović et al. [54] (2013) | (n = 24) | Monkeys | Not report | PRP with hydroxyapatite (HAP) | Glass ionomer cement (GIC) and amalgam | 6 months | Stage I (<1/2 root length with open apex) | Retardation of root development and nonsignificant differences among the samples. |
| Yamauchi et al. [58] (2011) | (n = 64) | Dogs | TAP | Blood clot | MTA | 3.5 months | Stage III (2/3 root length with open apex) | Periapical healing and root wall thickening |
| Zuong et al. [61] (2010) | (n = 6) | Dogs | TAP | Blood clot | MTA | 8 weeks | Stage V (closed apical foramen and completed root development) | Apical closure/Root thickening |
| Da Silva et al. [62] (2010) | (n = 40) | Dogs | (TAP) | Empty scaffold | MTA | 3 months | Stage IV (wide opening apical foramen and nearly completed root length) | Hard tissue barrier and increase of apical periodontal ligament thickness |
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