Synthesis and Evaluation of the Acetylcholinesterase Inhibitory Activities of Some Flavonoids Derived from Naringenin

Table 2

Predicted parameters by ProTox-II.

Classification	Target
Oral toxicity	LD50, toxicity class
Organ toxicity	Hepatotoxicity
Toxicity end points	Carcinogenicity, immunotoxicity, mutagenicity, and cytotoxicity
Tox21-nuclear receptor signalling pathways	Aryl hydrocarbon receptor (AhR), androgen receptor (AR), androgen receptor ligand binding domain (AR-LBD), aromatase, estrogen receptor alpha (ER), estrogen receptor ligand binding domain (ER-LBD), and peroxisome proliferator-activated receptor gamma (PPAR-gamma)
Tox21-stress response pathways	Nuclear factor (erythroid-derived 2)-like 2/antioxidant responsive element (nrf2/ARE), heat shock factor response element (HSE), mitochondrial membrane potential (MMP), phosphoprotein (tumor suppressor) p53, and ATPase family AAA domain-containing protein 5 (ATAD5)

LD50, median lethal dose; Tox21, toxicology in the 21st century (a unique collaboration between several US federal agencies to develop new ways to rapidly test whether substances adversely affect human health).