Comparative Study of Antiproliferative Activity in Different Plant Parts of Phaleria macrocarpa and the Underlying Mechanism of Action

Figure 9

Effect of P. macrocarpa leaf extract on the relative number of caspase-3, Bax, and Bcl-2 in T47D cells as assessed by flow cytometry analysis. T47D cells were treated with P. macrocarpa leaf extract at IC₅₀, 2x IC₅₀/2-fold of IC₅₀, and 4x IC₅₀/4-fold of IC₅₀ for 24 h. The representative histogram and graph showed the percentage of T47D cells which expressed (a) caspase-3, (b) Bax, and (c) Bcl-2. Data are presented as mean ± SD (n = 3). . : significant compared with the untreated control group; : significant compared with cisplatin group; : significant compared with cisplatin and IC₅₀ group; ns: no significant difference.

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(b)

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