The Scientific World Journal

Hemorheology and Sickle Cell Disease

Publishing date
29 May 2015
Submission deadline
09 Jan 2015

Lead Editor

1Thomas Jefferson University, Philadelphia, USA

2Emory University, Atlanta, USA

3Centre Hospitalier Universitaire (CHU) de Pointe-à-Pitre, Pointe-à-Pitre, France

4University of Southern California and Children’s Hospital Los Angeles, Los Angeles, USA

This issue is now closed for submissions.
More articles will be published in the near future.

Hemorheology and Sickle Cell Disease

This issue is now closed for submissions.
More articles will be published in the near future.


The inherited diseases of hemoglobin (Hb) structure are a heterogeneous group of disorders among which sickle cell anemia (SCA), a single gene defect, is the most common. Patients with SCA suffer from recurrent acute painful vasoocclusive crises, severe anemia, and progressive organ dysfunction. The fundamental pathophysiology of the disease stems from reduced red blood cell (RBC) deformability due to the polymerization of hemoglobin S (HbS), leading to RBC sickling, intra- and extravascular hemolysis, vascular occlusion, and recurrent ischemia of the affected organs. Moreover, inflammation, enhanced endothelial adhesion of circulating cells, thrombotic activation, impaired vascular reactivity, changes in blood viscosity, and RBC microrheology are involved in the complex pathophysiology of SCA. Although there are numerous publications on SCA and blood rheology, reports linking the hemorheologic properties of sickle blood to the clinical manifestations of SCA are scarce.

We invite investigators to submit original papers and reviews that will clarify the role of hemorheology in the pathophysiology of SCA, evaluate the outcomes of hemorheological interventions, and develop new strategies to manage SCA.

Potential topics include, but are not limited to:

  • Methodologies to determine deformability, viscosity, aggregation, and density distribution of sickle RBCs in the steady state
  • Characteristic circulatory changes in the micro- and macrocirculation in SCA
  • Changes in the hemorheologic properties of sickle RBCs during vasoocclusive crises or other disease complications
  • Differences in the hemorheologic properties of sickle RBCs in disease variants such as SCA, sickle-β 0-thalassemia, sickle-β +-thalassemia, and Hb SC disease
  • Implication of cell-cell and blood cell-vascular wall interactions in the pathophysiology of SCA
  • Molecular and cellular factors modulating sickle RBC properties
  • Transfusion, phlebotomy, blood rheology, and SCA
  • Microfluidic approaches in the field of SCA research
  • Pharmacologic agents affecting the hemorheologic characteristics of sickle RBCs
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