The Scientific World Journal

Innovative Targeting Strategies in Drug Therapy for Inflammatory Diseases: Mechanistic Approaches


Publishing date
20 Feb 2015
Status
Published
Submission deadline
03 Oct 2014

Lead Editor

1Taipei Medical University, Taipei, Taiwan

2Institute of Ophthalmology, Tiruchirappalli, India

3University of Nebraska Medical Center, Omaha, USA


Innovative Targeting Strategies in Drug Therapy for Inflammatory Diseases: Mechanistic Approaches

Description

The therapeutic management of inflammatory disease (ID) represents the perfect scenario for drug targeting to the site(s) of action. While existing formulation-based targeting strategies include dosage forms and oral systems that target the organs by pH-, time-, microflora-, and pressure-triggered drug release, novel approaches for site-specific delivery in ID therapy will target the inflamed organs per se. The therapy of ID is dominated by the administration of anti-inflammatory and immunosuppressive drugs, which suppress the inflammatory burden and improve the disease-related symptoms. Established treatment strategies are characterized by a limited therapeutical efficacy and the occurrence of adverse drug reactions. Thus, the development of novel disease-targeted drug delivery strategies is intended for a more effective therapy and demonstrates the potential to address unmet medical needs. Although various complementary and conventional treatment strategies have been incorporated into experimental and clinical practices, the relevant molecular mechanisms are still under investigation. So, we invite researchers to contribute original research articles as well as review articles that provide solid evidence to support the application of innovative drugs in prevention and treatment of inflammatory diseases.

Potential topics include, but are not limited to:

  • Recent advance in identifying active ingredients of nutritional and medicinal herbs against inflammatory diseases
  • Experimental and clinical trials of novel drugs on therapeutic treatments of cardiovascular diseases
  • Current applications of natural drugs or plant extracts in treatment of cerebral and coronary thrombosis using in vitro and in vivo models
  • Advances in revealing acting targets of bioactive compounds for the treatment of cancer, aging, and type 2 diabetes diseases
  • Nutritional features of metabolic inflammation in association to health insights for biomarkers in inflammatory diseases
  • Role of natural drugs in alleviating the oxidative stress, ROS, and organ inflammation
  • Association of MAPK signaling pathway and the downstream transcriptional factors NF-κB with anti-inflammatory treatment strategy

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 891676
  • - Editorial

Innovative Targeting Strategies in Drug Therapy for Inflammatory Diseases: Mechanistic Approaches

Duen-Suey Chou | Joen-Rong Sheu | ... | Muniyan Sakthivel
  • Special Issue
  • - Volume 2015
  • - Article ID 417124
  • - Research Article

VEGF Correlates with Inflammation and Fibrosis in Tuberculous Pleural Effusion

Mauo-Ying Bien | Ming-Ping Wu | ... | Chi-Li Chung
  • Special Issue
  • - Volume 2015
  • - Article ID 492683
  • - Research Article

Static Magnetic Field Attenuates Lipopolysaccharide-Induced Inflammation in Pulp Cells by Affecting Cell Membrane Stability

Sung-Chih Hsieh | Jeng-Ting Tsao | ... | Haw-Ming Huang
  • Special Issue
  • - Volume 2015
  • - Article ID 289647
  • - Research Article

Change of Scaling-Induced Proinflammatory Cytokine on the Clinical Efficacy of Periodontitis Treatment

Kou-Gi Shyu | Cheuk-Sing Choy | ... | Yung-Kai Huang
  • Special Issue
  • - Volume 2014
  • - Article ID 745802
  • - Research Article

Effect of Antrodia camphorata on Inflammatory Arterial Thrombosis-Mediated Platelet Activation: The Pivotal Role of Protein Kinase C

Wan-Jung Lu | Shih-Chang Lin | ... | Joen-Rong Sheu
  • Special Issue
  • - Volume 2014
  • - Article ID 686109
  • - Research Article

Extract of Antrodia camphorata Exerts Neuroprotection against Embolic Stroke in Rats without Causing the Risk of Hemorrhagic Incidence

Ye-Ming Lee | Chiu-Yun Chang | ... | Jie-Jen Lee
  • Special Issue
  • - Volume 2014
  • - Article ID 130381
  • - Research Article

Andrographolide Inhibits Nuclear Factor-B Activation through JNK-Akt-p65 Signaling Cascade in Tumor Necrosis Factor-α-Stimulated Vascular Smooth Muscle Cells

Yu-Ying Chen | Ming-Jen Hsu | ... | Joen-Rong Sheu
  • Special Issue
  • - Volume 2014
  • - Article ID 423259
  • - Research Article

Sanguis draconis, a Dragon’s Blood Resin, Attenuates High Glucose-Induced Oxidative Stress and Endothelial Dysfunction in Human Umbilical Vein Endothelial Cells

Yi Chang | Ting-Chen Chang | ... | Thanasekaran Jayakumar
The Scientific World Journal
 Journal metrics
Acceptance rate24%
Submission to final decision97 days
Acceptance to publication42 days
CiteScore1.430
Impact Factor-
 Submit

We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at help@hindawi.com to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19.