The Scientific World Journal

Toxicology and Disease/Cancer Therapy in Reactive Oxygen Species-Mediated Drugs and Treatments


Publishing date
20 Feb 2015
Status
Published
Submission deadline
03 Oct 2014

Lead Editor

1Kaohsiung Medical University, Kaohsiung, Taiwan

2University of Louisville, Louisville, USA

3I-Shou University, Kaohsiung, Taiwan

4SK University of Agricultural Sciences and Technology, Chatha, India


Toxicology and Disease/Cancer Therapy in Reactive Oxygen Species-Mediated Drugs and Treatments

Description

Many anticancer agents and/or natural products may modulate the level of reactive oxygen species (ROS) and induce or protect cellular oxidative damage. ROS has also been reported to be involved in apoptosis, autophagy, endoplasmic reticulum (ER) stress, mitochondrial dysfunction, cell migration, and invasion. Although many ROS modulating drugs affect the proliferative ability of cancer cells, they may also generate various side effects on normal cells. Accordingly, the toxicology and disease/cancer therapy in ROS-mediated drugs and treatments are still challenging.

The overall aim of this special issue is to present the recent advances in both benefit and side effects and signaling mechanisms for anticancer and disease therapeutic drugs and/or natural products based on their ROS modulation ability. Furthermore, the aim of this issue also provides the innovative reviews of the features of ROS modulation of anticancer and disease therapeutic drugs and/or natural products in cell-based studies, animal model, and clinical application.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts on exploring the ROS modulating effects and downstream signaling mechanisms for ROS-mediated drugs and/or natural products for drug chemoprevention, chemotherapy, and disease therapy, as well as the emerging pharmacogenomics issues. ROS modulating effects of drugs on noncancer diseases, antibacteria, and antivirus are also welcome.

Potential topics include, but are not limited to:

  • Anticancer drugs
  • Natural products
  • Toxicology
  • ROS
  • RNS
  • Signal transduction
  • Apoptosis
  • Autophagy
  • Endoplasmic reticulum (ER) stress
  • DNA damage
  • DNA repair
  • Bioassay
  • Chemical engineering
  • Antioxidant
  • Chemoprevention
  • Chemotherapy
  • Single nucleotide polymorphism (SNP)

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 860563
  • - Editorial

Toxicology and Disease/Cancer Therapy in Reactive Oxygen Species-Mediated Drugs and Treatments

Hsueh-Wei Chang | Shao-Yu Chen | ... | Sanjay Guleria
  • Special Issue
  • - Volume 2015
  • - Article ID 303415
  • - Research Article

Evaluation of Cinnamomum osmophloeum Kanehira Extracts on Tyrosinase Suppressor, Wound Repair Promoter, and Antioxidant

Man-Gang Lee | Su-Yu Kuo | ... | Hui-Min David Wang
  • Special Issue
  • - Volume 2015
  • - Article ID 740815
  • - Research Article

Discovery of Specific Inhibitors for Intestinal E. coli  β-Glucuronidase through In Silico Virtual Screening

Ta-Chun Cheng | Kuo-Hsiang Chuang | ... | Chien-Shu Chen
  • Special Issue
  • - Volume 2015
  • - Article ID 620826
  • - Research Article

Indoxyl Sulfate-Induced Oxidative Stress, Mitochondrial Dysfunction, and Impaired Biogenesis Are Partly Protected by Vitamin C and N-Acetylcysteine

Wen-Chin Lee | Lung-Chih Li | ... | Hsueh-Wei Chang
  • Special Issue
  • - Volume 2015
  • - Article ID 160185
  • - Research Article

Association Study between Novel CYP26 Polymorphisms and the Risk of Betel Quid-Related Malignant Oral Disorders

Shyh-Jong Wu | Yun-Ju Chen | ... | Ping-Ho Chen
  • Special Issue
  • - Volume 2014
  • - Article ID 180462
  • - Research Article

Antiproliferative Effects of Methanolic Extracts of Cryptocarya concinna Hance Roots on Oral Cancer Ca9-22 and CAL 27 Cell Lines Involving Apoptosis, ROS Induction, and Mitochondrial Depolarization

Hurng-Wern Huang | Yi-An Chung | ... | Hsueh-Wei Chang
  • Special Issue
  • - Volume 2014
  • - Article ID 183548
  • - Research Article

The Influence of Monoamine Oxidase Variants on the Risk of Betel Quid-Associated Oral and Pharyngeal Cancer

Ping-Ho Chen | Bin Huang | ... | Ka-Wo Lee
  • Special Issue
  • - Volume 2014
  • - Article ID 754721
  • - Research Article

A Proteomics Analysis to Evaluate Cytotoxicity in NRK-52E Cells Caused by Unmodified Nano-Fe3O4

Yi-Reng Lin | Chao-Jen Kuo | ... | Shih-Shin Liang
  • Special Issue
  • - Volume 2014
  • - Article ID 937051
  • - Research Article

The Antiproliferative and Apoptotic Effects of Sirtinol, a Sirtuin Inhibitor on Human Lung Cancer Cells by Modulating Akt/β-Catenin-Foxo3A Axis

Yao Fong | Yin-Chieh Lin | ... | Chien-Chih Chiu
  • Special Issue
  • - Volume 2014
  • - Article ID 360153
  • - Research Article

Arsenic Modulates Posttranslational S-Nitrosylation and Translational Proteome in Keratinocytes

Bin Huang | Kuo-Hao Chiang | ... | Wei-Ting Liao
The Scientific World Journal
 Journal metrics
Acceptance rate23%
Submission to final decision80 days
Acceptance to publication44 days
CiteScore1.430
Impact Factor-
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