Potential Application of Probiotics in the Prevention and Treatment of Inflammatory Bowel Diseases

Table 3

Examples of genetically modified (GM) bacterial strains with proven antiinflammatory properties classified by their mechanisms of action.

Mechanism	Strain*	Proven effects	Reference
Immune	L. plantarum NCIMB8826ΔDlt	Reduction of secretion of proinflammatory cytokines by peripheral blood mononuclear cells and monocytes and increase in IL-10 production in a murine colitis model	[116]
	Lc. lactis IL-10	Reduction of colitis in mice treated with DSS and prevention of the onset of colitis in IL-10 knockout mice.	[101]
		Attenuation of the severity of inflammation in CD patients	[102]
		Regulation of inflammatory cascades in an asthma model	[103]
CAT	L. casei BL23 MnKat	Reduction of cecal and colonic inflammatory scores in a DSS-induced colitis model	[117]
		Significat reduction of physiological damages in a TNBS-induced colitis model	[121]
	Lc. lactis + KatE	Slight increase catalase activity in the intestines and prevention of colon cancer or mice administered the cancer inducing drug DMH	[118]
SOD	Lc. lactis NZ9811 and L. plantarum NCIMB8826+pNZ804 sodA	Reduction in macroscopic damages in rats administered TNBS to induce colitis	[119]
	L. gasseri NC1501 (sod overexpression)	Reduction of inflammation in IL-10 deficient mice	[8]
	L. casei BL23 + sodA	Attenuation of colonic histological damage scores in a DSS-induced colitis model.	[120]
		Significat reduction of physiological damages in a TNBS-induced colitis model.	Unpublished data