Antioxidant Capacity, Cytoprotection, and Healing Actions of the Leaf Aqueous Extract of Ocimum suave in Rats Subjected to Chronic and Cold-Restraint Stress Ulcers

Table 3

Healing effect of the leaf aqueous extract of O. suave on chronic acetic acid-induced gastric ulcers in rats.

Treatment	Extracted dose (mg/kg)	𝑁	Ulcerated area (mm^2)	% Healing	Mucus production (mg)	Stomach relative weight (%)
Healthy control	—	6	0	—	60.53±3.83	1.05±0.04
Group 1	—	6	81.00±13.37	—	55.26±3.38	1.79±0.16^Ψ
Group 2	—	6	47.00±2.49	41.9	54.25±4.14	1.25±0.13
Group 3	125	6	7.30±3.35	84.5**	52.39±2.24	1.05±0.07
Group 4	250	6	4.05±1.64	91.4**	72.60±7.99^∗	0.97±0.07
Group 5	500	6	3.20±1.53	93.2**	75.71±7.24^∗	1.09±0.12
Group 6 (ranitidine)	50	6	9.20±2.15	80.4**	58.13±4.39	1.22±0.15

𝑁: number of rats.
Statistically different relative to group 2, ^∗𝑃<0.05,^∗∗𝑃<0.01.
Statistically different relative to group 1, ^Ψ𝑃<0.01.
Healthy control: healthy, nonulcerated control rats.
Group 1 (ulcerated rats sacrificed 4 days after acetic acid ulcer induction), showing a deep large ulcer (about 81 mm²), with raised edges and sclerous interior.
Group 2 (ulcerated rats given vehicle for 14 days following ulcer induction).
Groups 3, 4, and 5 ulcerated rats treated with 125, 250, and 500 mg/kg bw of extract, respectively, for 14 d after day 4 of ulcer establishment.
Positive control rat given ranitidine (50 mg/kg bw) for 14 d after ulcer establishment.