Table of Contents
Volume 2013, Article ID 219257, 4 pages
Research Article

Chronic Nonhealing Wounds: Could Leg Ulcers Be Hereditary?

1Department of Medical Genetics, University of Szeged, 4 Somogyi B utca, H-6720 Szeged, Hungary
2Dermatological Research Group of the Hungarian Academy of Sciences, University of Szeged, 6 Korányi fasor, H-6720 Szeged, Hungary
3Department of Dermatology and Allergology, University of Szeged, 6 Korányi fasor, H-6720 Szeged, Hungary

Received 4 September 2012; Revised 30 January 2013; Accepted 17 February 2013

Academic Editor: Marco A. C. Frade

Copyright © 2013 Nikoletta Nagy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. A number of well-known acquired and putative inherited etiological factors contribute to the development of venous leg ulcer (VLU). Aim. In this study we set out to perform a meta-analysis of putative genetic and acquired factors predisposing to VLU development. Methods. VLU patients ( ) were divided into three subgroups in accordance with their acquired etiological factors. The frequencies of four genetic factors were determined: the R506Q (Leiden) mutation of the F5 gene, the G20210A mutation of the F2 (prothrombin) gene, the 2451 A/G SNP of the fibroblast growth factor receptor 2 (FGFR2) 3′ UTR, and the −308 G/A SNP of the tumor necrosis factor α (TNFA) promoter. Results. The −308 TNFA SNP exhibited a higher frequency among VLU patients without known acquired predisposing factor in their history, than among patients with thrombosis or soft tissue infection in their history (Fisher ). Conclusions. This study has demonstrated that the group of VLU patients is heterogeneous in their genetic predisposing factors. Further large-scale studies are needed to delineate the associations among genetic and acquired etiological factors with regard to VLU development and to integrate the consequences of the already known genetic factors to the management of VLU.