Table of Contents
Ulcers
Volume 2014, Article ID 184736, 5 pages
http://dx.doi.org/10.1155/2014/184736
Research Article

Urease Inhibitory Activity of Aerial Parts of Artemisia scoparia: Exploration in an In Vitro Study

1Department of Chemistry, Kohat University of Science and Technology, Kohat 26000, Pakistan
2Department of Pharmacy, Abdul Wali Khan University Mardan, Mardan 23200, Pakistan
3Institute of Basic Medical Sciences, Khyber Medical University, Peshawar 25210, Pakistan
4Department of Pharmacy, University of Peshawar, Peshawar 25210, Pakistan

Received 18 October 2013; Revised 30 November 2013; Accepted 17 December 2013; Published 16 January 2014

Academic Editor: Takafumi Ando

Copyright © 2014 Murad Ali Khan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Artimisia scoparia has been used in the treatment of different disorders including ulcers. The current study was therefore designed to investigate the aerial parts of  Artemisia scoparia (crude extract, total sterol and flavonoidal contents, and aqueous fraction) for its urease inhibitory potential. The crude of the plant evoked marked attenuation on urease activity, when tested in various concentrations with IC50 values of 4.06 mg/ml. The inhibitory potential was further augmented in the aqueous fraction (IC50: 2.30 mg/ml) of the plant. When the total sterol and flavonoidal contents were challenged against urease, both showed concentration dependent activity; the latter showed maximum potency with IC50 values of 8.04 and 2.10 mg/ml, respectively. In short, the aerial parts of the plant demonstrated marked antagonism on urease and thus our study validated the traditional use of Artemisia scoparia in the treatment of ulcer.