Lycopene Prevents Development of Steatohepatitis in Experimental Nonalcoholic Steatohepatitis Model Induced by High-Fat Diet

Table 2

The effects of lycopene on serum parameters in groups.

Parameter	Control group ($n=10$)	HFD ($n=10$)	HFD $+$ 2 mg/kg lycopene ($n=9$)	HFD $+$ 4 mg/kg lycopene ($n=10$)
Insulin ($\mu$IU/mL )	$\mathrm{0,129}\pm \mathrm{0,069}$	$\mathrm{0,132}\pm \mathrm{0,028}$	$\mathrm{0,116}\pm \mathrm{0,340}$	$\mathrm{0,102}\pm \mathrm{0,0230}$
HOMA-R	$0.032\pm \mathrm{0,02}$	$\mathrm{0,043}\pm \mathrm{0,02}$	$\mathrm{0,036}\pm 0.01$	$\mathrm{0,034}\pm 0.06$
Glucose (mg/dL)	$\mathrm{127,33}\pm \mathrm{12,30}$	$\mathrm{139,11}\pm \mathrm{9,25}$	$\mathrm{130,22}\pm \mathrm{8,89}$ *	$\mathrm{139,55}\pm \mathrm{14,53}$
Triglyceride (mg/dL)	67,2±14,2	$\mathrm{189,5}\pm \mathrm{93,7}$^†	$\mathrm{157,3}\pm \mathrm{56,8}$	$\mathrm{130,9}\pm \mathrm{33,3}$ *
Cholesterol (mg/dL)	$\mathrm{49,80}\pm \mathrm{5,76}$	$\mathrm{71,7}\pm \mathrm{6,2}$	$\mathrm{78,4}\pm 20.2$	$\mathrm{71,0}\pm \mathrm{5,18}$
ALT (IU/L)	$\mathrm{84,1}\pm \mathrm{7,3}$	$\mathrm{96,2}\pm \mathrm{11,4}$^†	$\mathrm{85,8}\pm \mathrm{7,4}$ *	$\mathrm{81,2}\pm \mathrm{15,7}$ *
AST (IU/L)	$\mathrm{174,4}\pm \mathrm{14,5}$	$\mathrm{247,3}\pm \mathrm{21,7}$^†	$\mathrm{231,7}\pm \mathrm{38,5}$	$\mathrm{238,0}\pm \mathrm{20,16}$
ALP (IU/L)	$\mathrm{213,3}\pm \mathrm{63,7}$	$\mathrm{467,3}\pm \mathrm{87,9}$^†	$\mathrm{440,5}\pm \mathrm{108,0}$	$\mathrm{414,5}\pm \mathrm{113,3}$
GGT (IU/L)	$\mathrm{1,3}\pm \mathrm{0,4}$	$\mathrm{1,8}\pm \mathrm{1,2}$	$1.1\pm 0.60$	$\mathrm{1,7}\pm 0.9$^†
TNF-α (pg/mL)	$\mathrm{0,192}\pm \mathrm{0,50}$	$\mathrm{0,615}\pm \mathrm{0,358}$^†	$\mathrm{0,226}\pm \mathrm{0,126}$ *	$\mathrm{0,254}\pm \mathrm{0,186}$ *

* $P<.05$: compared with HFD group; ^†$P<.05$: compared with control.