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Veterinary Medicine International
Volume 2010, Article ID 727231, 6 pages
http://dx.doi.org/10.4061/2010/727231
Research Article

Disposition Kinetics of Levofloxacin in Sheep after Intravenous and Intramuscular Administration

1Pharmacology Department, Faculty of Veterinary Medicine, Cairo University, Giza, P.O. Box 12211, Egypt
2College of Pharmacy, Ohio State University, Columbus, OH 43210, USA

Received 31 May 2010; Revised 29 July 2010; Accepted 5 October 2010

Academic Editor: William Ravis

Copyright © 2010 Ayman Goudah and Sherifa Hasabelnaby. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Martinez, P. McDermott, and R. Walker, “Pharmacology of the fluoroquinolones: a perspective for the use in domestic animals,” Veterinary Journal, vol. 172, no. 1, pp. 10–28, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  2. R. Davis and H. M. Bryson, “Levofloxacin: a review of its antibacterial activity, pharmacokinetics and therapeutic efficacy,” Drugs, vol. 47, no. 4, pp. 677–700, 1994. View at Google Scholar · View at Scopus
  3. N. Klesel, K. H. Geweniger, and K. H. Geweniger, “Chemotherapeutic activity of levofloxacin (HR 355, DR-3355) against systemic and localized infections in laboratory animals,” Journal of Antimicrobial Chemotherapy, vol. 35, no. 6, pp. 805–819, 1995. View at Google Scholar · View at Scopus
  4. J. S. Wolfson and D. C. Hooper, “Fluoroquinolone antimicrobial agents,” Clinical Microbiology Reviews, vol. 2, no. 4, pp. 378–424, 1989. View at Google Scholar · View at Scopus
  5. K. Drlica and X. Zhao, “DNA gyrase, topoisomerase IV, and the 4-quinolones,” Microbiology and Molecular Biology Reviews, vol. 61, no. 3, pp. 377–392, 1997. View at Google Scholar · View at Scopus
  6. G. A. Albarellos, L. A. Ambros, and M. F. Landoni, “Pharmacokinetics of levofloxacin after single intravenous and repeat oral administration to cats,” Journal of Veterinary Pharmacology and Therapeutics, vol. 28, no. 4, pp. 363–369, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. G. L. Drusano, D. E. Johnson, M. Rosen, and H. C. Standiford, “Pharmacodynamics of a fluoroquinolone antimicrobial agent in a neutropenic rat model of Pseudomonas sepsis,” Antimicrobial Agents and Chemotherapy, vol. 37, no. 3, pp. 483–490, 1993. View at Google Scholar · View at Scopus
  8. F. S. Aliabadi and P. Lees, “Pharmacokinetics and pharmacodynamics of danofloxacin in serum and tissue fluids of goats following intravenous and intramuscular administration,” American Journal of Veterinary Research, vol. 62, no. 12, pp. 1979–1989, 2001. View at Google Scholar · View at Scopus
  9. J. M. Hyatt, P. S. McKinnon, G. S. Zimmer, and J. J. Schentag, “The importance of pharmacokinetic/pharmacodynamic surrogate markers to outcome: focus on antibacterial agents,” Clinical Pharmacokinetics, vol. 28, no. 2, pp. 143–160, 1995. View at Google Scholar · View at Scopus
  10. J. B. Meinen, J. T. McClure, and E. Rosin, “Pharmacokinetics of enrofloxacin in clinically normal dogs and mice and drug pharmacodynamics in neutropenic mice with Escherichia coli and staphylococcal infections,” American Journal of Veterinary Research, vol. 56, no. 9, pp. 1219–1224, 1995. View at Google Scholar · View at Scopus
  11. W. A. Craig, “Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men,” Clinical Infectious Diseases, vol. 26, no. 1, pp. 1–12, 1998. View at Google Scholar · View at Scopus
  12. H. D. Langtry and H. M. Lamb, “Levofloxacin: its use in infections of the respiratory tract, skin, soft tissues and urinary tract,” Drugs, vol. 56, no. 3, pp. 487–515, 1998. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Hurst, H. M. Lamb, L. J. Scott, and D. P. Figgitt, “Levofloxacin: an updated review of its use in the treatment of bacterial infections,” Drugs, vol. 62, no. 14, pp. 2127–2167, 2002. View at Google Scholar · View at Scopus
  14. A. Anadon, M. R. Martinez-Larranaga, and M. R. Martinez-Larranaga, “Pharmacokinetics and residues of enrofloxacin in chickens,” American Journal of Veterinary Research, vol. 56, no. 4, pp. 501–506, 1995. View at Google Scholar · View at Scopus
  15. A. Anadón, M. R. Martínez-Larrañaga, and M. R. Martínez-Larrañaga, “Pharmacokinetic characteristics and tissue residues for marbofloxacin and its metabolite N-desmethyl-marbofloxacin in broiler chickens,” American Journal of Veterinary Research, vol. 63, no. 7, pp. 927–933, 2002. View at Google Scholar · View at Scopus
  16. A. Anadón, M. A. Martínez, M. Martínez, C. De La Cruz, M. J. Díaz, and M. R. Martínez-Larrañaga, “Oral bioavailability, tissue distribution and depletion of flumequine in the food producing animal, chicken for fattening,” Food and Chemical Toxicology, vol. 46, no. 2, pp. 662–670, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  17. F. C. Cheng, T. R. Tsai, Y. F. Chen, L. C. Hung, and T. H. Tsai, “Pharmacokinetic study of levofloxacin in rat blood and bile by microdialysis and high-performance liquid chromatography,” Journal of Chromatography A, vol. 961, no. 1, pp. 131–136, 2002. View at Publisher · View at Google Scholar · View at Scopus
  18. C. J. Destache, C. B. Pakiz, C. Larsen, H. Owens, and A. K. Dash, “Cerebrospinal fluid penetration and pharmacokinetics of levofloxacin in an experimental rabbit meningitis model,” Journal of Antimicrobial Chemotherapy, vol. 47, no. 5, pp. 611–615, 2001. View at Google Scholar · View at Scopus
  19. V. K. Dumka and A. K. Srivastava, “Pharmacokinetics, urinary excretion and dosage regimen of levofloxacin following a single intramuscular administration in cross bred calves,” Journal of Veterinary Science, vol. 7, no. 4, pp. 333–337, 2006. View at Google Scholar · View at Scopus
  20. V. K. Dumka and A. K. Srivastava, “Disposition kinetics, urinary excretion and dosage regimen of levofloxacin formulation following single intravenous administration in crossbred calves,” Veterinary Research Communications, vol. 31, no. 7, pp. 873–879, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  21. A. Goudah and K. Abo-El-Sooud, “Pharmacokinetics, urinary excretion and milk penetration of levofloxacin in lactating goats,” Journal of Veterinary Pharmacology and Therapeutics, vol. 32, no. 1, pp. 101–104, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  22. G. A. Albarellos, L. A. Ambros, and M. F. Landoni, “Pharmacokinetics of levofloxacin after single intravenous and repeat oral administration to cats,” Journal of Veterinary Pharmacology and Therapeutics, vol. 28, no. 4, pp. 363–369, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  23. A. Goudah, “Pharmacokinetics of levofloxacin in male camels (Camelus dromedarius),” Journal of Veterinary Pharmacology and Therapeutics, vol. 32, no. 3, pp. 296–299, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  24. A. Goudah, K. Abo El-Sooud, J.-H. Shim, H.-C. Shin, and A. M. Abd El-Aty, “Characterization of the pharmacokinetic disposition of levofloxacin in stallions after intravenous and intramuscular administration,” Journal of Veterinary Pharmacology and Therapeutics, vol. 31, no. 5, pp. 399–405, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  25. M. I. R. M. Santoro, N. M. Kassab, A. K. Singh, and E. R. M. Kedor-Hackmam, “Quantitative determination of gatifloxacin, levofloxacin, lomefloxacin and pefloxacin fluoroquinolonic antibiotics in pharmaceutical preparations by high-performance liquid chromatography,” Journal of Pharmaceutical and Biomedical Analysis, vol. 40, no. 1, pp. 179–184, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  26. A. W. Craig and B. Suh, “Protein binding and the antibacterial effects. Method for the determination of protein binding,” in Antibiotics in laboratory Medicine, V. Lorian, Ed., pp. 367–402, Williams & Wilkins, Baltimore, Md, USA, 3rd edition, 1991. View at Google Scholar
  27. K. Yamaoka, T. Nakagawa, and T. Uno, “Statistical moments in pharmacokinetics,” Journal of Pharmacokinetics and Biopharmaceutics, vol. 6, no. 6, pp. 547–558, 1978. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Gibaldi and D. Perrier, Pharmacokinetics, Marcel Dekker, New York, NY, USA, 2nd edition, 1982.
  29. S. A. Marshall and R. N. Jones, “In vitro activity of DU-6859a, a new fluorocyclopropyl quinolone,” Antimicrobial Agents and Chemotherapy, vol. 37, no. 12, pp. 2747–2753, 1993. View at Google Scholar · View at Scopus
  30. P. L. Toutain and A. Bousquet-Mélou, “Volumes of distribution,” Journal of Veterinary Pharmacology and Therapeutics, vol. 27, no. 6, pp. 441–453, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  31. S. A. Brown, “Fluoroquinolones in animal health,” Journal of Veterinary Pharmacology and Therapeutics, vol. 19, no. 1, pp. 1–14, 1996. View at Google Scholar · View at Scopus
  32. E. Fernández-Varón, L. Villamayor, E. Escudero, A. Espuny, and C. M. Cárceles, “Pharmacokinetics and milk penetration of moxifloxacin after intravenous and subcutaneous administration to lactating goats,” Veterinary Journal, vol. 172, no. 2, pp. 302–307, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  33. J.-L. Riond, K. Tyczkowska, and J. E. Riviere, “Pharmacokinetics and metabolic inertness of doxycycline in calves with mature or immature rumen function,” American Journal of Veterinary Research, vol. 50, no. 8, pp. 1329–1333, 1989. View at Google Scholar · View at Scopus
  34. A. Goudah, “Disposition kinetics of moxifloxacin in lactating ewes,” Veterinary Journal, vol. 178, no. 2, pp. 282–287, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  35. J. Turnidge, “Pharmacokinetics and pharmacodynamics of fluoroquinolones,” Drugs, vol. 58, no. 2, pp. 29–36, 1999. View at Publisher · View at Google Scholar · View at Scopus
  36. G. Zlotos, A. Bücker, M. Kinzig-Schippers, F. Sorgel, and U. Holzgrabe, “Plasma protein binding of gyrase inhibitors,” Journal of Pharmaceutical Sciences, vol. 87, no. 2, pp. 215–220, 1998. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  37. H. Lode, K. Borner, and P. Koeppe, “Pharmacodynamics of fluoroquinolones,” Clinical Infectious Diseases, vol. 27, no. 1, pp. 33–39, 1998. View at Google Scholar · View at Scopus
  38. P. L. Toutain, J. R. E. Del Castillo, and A. Bousquet-Mélou, “The pharmacokinetic-pharmacodynamic approach to a rational dosage regimen for antibiotics,” Research in Veterinary Science, vol. 73, no. 2, pp. 105–114, 2002. View at Publisher · View at Google Scholar · View at Scopus
  39. R. D. Walker, “The use of fluoroquinolones for companion animal antimicrobial therapy,” Australian Veterinary Journal, vol. 78, no. 2, pp. 84–90, 2000. View at Google Scholar · View at Scopus