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Veterinary Medicine International
Volume 2010, Article ID 768438, 5 pages
Research Article

Some Immunohormonal Changes in Experimentally Pregnant Toxemic Goats

1Department of Internal Medicine, Faculty of Veterinary Medicine, Benha University, Moshtohor 13736, Egypt
2Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, Moshtohor 13736, Egypt
3Department of Physiology, Faculty of Veterinary Medicine, Benha University, Moshtohor 13736, Egypt

Received 15 March 2010; Revised 12 May 2010; Accepted 18 May 2010

Academic Editor: Ingo Nolte

Copyright © 2010 Abd-Elghany Hefnawy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Pregnancy toxemia was induced in nine pregnant goat does with twins by the stress of fasting with access to water in late pregnancy to investigate the effect of pregnancy toxemia on immunoglobulins (IgA, IgM, and IgG), cortisol, insulin, thyroid, and growth hormones and their correlations with the plasma levels of glucose and 𝛽 -Hydroxybutyrate. Plasma samples were collected at 0, 12, 24, 36, 48, and 72 hours after induction of pregnancy toxemia. The result revealed that experimental animals developed neurological findings with convulsions and acetone odor from the mouth with recumbency after 72 hours. Laboratory findings showed a significant increase in 𝛽 -Hydroxybutyrate, cortisol, and insulin while there were significant decreases in glucose, thyroid, and immunoglobulins (IgA, IgM, and IgG). Plasma glucose concentrations had significant negative correlations with 𝛽 -hydroxybutyrate, cortisol, and insulin while the correlations were significantly positive with immunoglobulins and thyroid hormone. Plasma 𝛽 -hydroxybutyrate concentration was significantly positively correlated with cortisol and negatively correlated with immunoglobulins, insulin, and thyroid hormone. From this study we can conclude that pregnancy toxemia might affect humoral immune responses as well as insulin, cortisol, and thyroid hormones. Moreover, insulin might have a compensatory role to increase suppressive effect on ketogenesis in experimentally pregnant toxemic goats.