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Veterinary Medicine International
Volume 2011, Article ID 829054, 6 pages
Research Article

Effects of Acute Normovolemic Anemia on Hemodynamic Parameters and Acid-Base Balance in Dogs

Department of Animal Surgery and Clinical Sciences, Faculty of Agricultural and Veterinary Sciences (FCAV), São Paulo State University (UNESP), Via de Acesso Professor Paulo Donato Castellane, km 5, 14884-900 Jaboticabal, SP, Brazil

Received 27 October 2010; Revised 7 January 2011; Accepted 18 February 2011

Academic Editor: Remo G. Lobetti

Copyright © 2011 Tatiana Champion et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this study was to evaluate the hemodynamic and acid-base status of dogs subjected to acute normovolemic anemia. The dogs ( ) were evaluated 15 minutes and 24 hours after induction of anemia (hematocrit below 18%) with blood withdrawal and simultaneously replacement of same volume of Ringer's lactate solution and hydroxyethyl starch-based solution in a 2 : 1 ratio. The cardiac output was measured by Doppler echocardiography and blood pressure by oscillometric device, and posteriorly hemodynamic parameters were calculated. The anemic groups had increase in cardiac index ( to and  L/min   m2) and decreases in the indices of total peripheral resistance ( to and dina·seg/cm5  m2) and oxygen delivery ( to and  mL/min   m2), respectively. There were no significant changes in pH, but PaO2 and SaO2 values were increased, and PaCO2 reduced in anemic dogs . Therefore, acute normovolemic anemia can create significant hemodynamic changes and despite some hemogasometric changes, there were no changes in the acid-base status in dogs.