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Veterinary Medicine International
Volume 2011, Article ID 905153, 8 pages
http://dx.doi.org/10.4061/2011/905153
Review Article

Antioxidants and the Integrity of Ocular Tissues

1Escuela de Graduados, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, P.O. Box 567, 5110566 Valdivia, Chile
2Instituto de Ciencias Clínicas Veterinarias, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, P.O. Box 567, 5110566 Valdivia, Chile

Received 1 January 2011; Revised 21 March 2011; Accepted 13 May 2011

Academic Editor: Fernando Wittwer Menge

Copyright © 2011 Marcela P. Cabrera and Ricardo H. Chihuailaf. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Oxygen-derived free radicals are normally generated in many pathways. These radicals can interact with various cellular components and induce cell injury. When free radicals exceed the antioxidant capacity, cell injury causes diverse pathologic changes in the organs. The imbalance between the generation of free radicals and antioxidant defence is known as oxidative stress. The eye can suffer the effect of oxidative damage due to the etiopathogenesis of some pathological changes related to oxidative stress. This paper reviews the role of oxidative stress in the onset and progression of damage in different eye structures, the involvement of the antioxidant network in protecting and maintaining the homeostasis of this organ, and the potential assessment methodologies used in research and in some cases in clinical practice.