Figure 7: Effect of no treatment (□) or bolus administration of 5 g CuO wire particles (about 0.1 g Cu/kg LW) (■) administered to pregnant ewes early in gestation on the concentrations of Cu in (a) serum, and (b) liver of ewes (□, ■) and their lambs (∆, ▲). Although the flock was not initially Cu deficient, efficacy of CuO particles was demonstrated by changes in liver Cu concentrations [14].