A Population Pharmacokinetic Approach to Describe Cephalexin Disposition in Adult and Aged Dogs

Table 3

Parameter estimates of the base and the final population pharmacokinetic model for cephalexin.

Parameter	Base model mean estimate (s.e)	Final model mean estimate^a (s.e)
Tlag (h)	0.245 (0.082)	0.143 (0.051)
Ka (h^−1)	1.40 (0.15)	1.39 (0.15)
Vd/F (mL/kg)	642 (44)	565 (30)
Ke/F (h^−1)	0.341 (0.014)	0.340 (0.014)
Residual variability
Proportional (%)	0.131 (0.009)	0.133 (0.009)
Additive (mg/L)	0.112 (0.036)	0.100 (0.03)

Tlag: lag-time; ke/F, apparent elimination rate constant; Vd/F, apparent volume of distribution.
^aThe final model corresponds to Tlag (h) = 0.144 ; Vd/F (mL/kg) = 565 ; Ke (h⁻¹) = 0.34 .