Effects of Eplerenone on Blood Pressure and Echocardiographic and Serum Biochemical Variables in Five Healthy Dogs: A Pilot Study

Table 1

Peak velocity of early diastolic transmitral flow (E), peak velocity of late transmitral flow (A), ratio of the peak velocity of early diastolic transmitral flow to the peak velocity of late transmitral flow (E/A), deceleration time of early diastolic transmitral flow (DT_E), and ratio of the peak velocity of early diastolic transmitral flow to peak the velocity of early diastolic septal mitral annular motion (E/E′) values after eplerenone (EP) administration in dogs.

Variables	Group	Time after EP administration (weeks)
		0	1	2	4
E (cm/s)	EP 2.5	75.8 ± 5.8	66.6 ± 7.3	66.6 ± 3.1	64.1 ± 4.2
	EP 5	64.9 ± 2.3	60.7 ± 3.0	59.4 ± 2.4	60.3 ± 1.6
	EP 10	73.5 ± 3.2	58.0 ± 3.0^b	61.1 ± 2.1^a	58.0 ± 1.7^b
A (cm/s)	EP 2.5	50.4 ± 3.8	51.3 ± 8.9	45.5 ± 3.7	46.1 ± 5.0
	EP 5	36.3 ± 2.6	40.2 ± 1.7	44.8 ± 4.2	39.7 ± 3.0
	EP 10	42.7 ± 1.7	43.5 ± 2.8	42.2 ± 2.7	36.5 ± 2.2
E/A	EP 2.5	1.51 ± 0.06	1.38 ± 0.13	1.49 ± 0.08	1.44 ± 0.13
	EP 5	1.82 ± 0.14	1.52 ± 0.09	1.35 ± 0.09^a	1.54 ± 0.08
	EP 10	1.72 ± 0.03	1.34 ± 0.08^a	1.47 ± 0.11	1.60 ± 0.06
DTE (ms)	EP 2.5	85.4 ± 2.9	111.6 ± 8.2	106.8 ± 5.8	103.2 ± 7.9
	EP 5	78.0 ± 5.4	97.2 ± 3.5	105.6 ± 8.2^a	111.6 ± 8.6^a
	EP 10	76.8 ± 6.7	102.0 ± 6.0	102.0 ± 11.7	104.4 ± 10.1
E/E′	EP 2.5	9.4 ± 0.5	7.7 ± 0.6	7.0 ± 0.1^b	7.6 ± 0.4^a
	EP 5	8.0 ± 0.4	6.8 ± 0.4	6.9 ± 0.3	7.6 ± 0.3
	EP 10	9.8 ± 0.5	7.0 ± 0.6^b	7.2 ± 0.6^b	7.3 ± 0.3^a

Each value represents the mean ± standard error (). EP 2.5, 5, and 10: eplerenone 2.5, 5, and 10 mg/kg, respectively. ^a,bValue differs significantly (^a; ^b) from the baseline (time 0) value.