Effects of Eplerenone on Blood Pressure and Echocardiographic and Serum Biochemical Variables in Five Healthy Dogs: A Pilot Study
Table 2
Peak velocity of early diastolic septal mitral annular motion (E′), peak velocity of diastolic septal mitral annular motion (A′), ratio of the peak velocity of early diastolic mitral annular motion to the peak velocity of diastolic mitral annular motion (E′/A′), mid systolic myocardial velocity gradient (MVGs), early diastolic myocardial velocity gradient (MVGe), and atrial systolic myocardial velocity gradient (MVGa) after eplerenone (EP) administration in dogs.
Variables
Group
Time after EP administration (weeks)
0
1
2
4
E′ (cm/s)
EP 2.5
8.1 ± 0.4
8.6 ± 0.6
9.5 ± 0.5
8.5 ± 0.4
EP 5
8.1 ± 0.3
9.0 ± 0.4
8.7 ± 0.5
8.0 ± 0.4
EP 10
7.6 ± 0.6
8.4 ± 0.7
8.7 ± 0.8
8.1 ± 0.5
A′ (cm/s)
EP 2.5
5.7 ± 0.4
5.9 ± 0.3
6.3 ± 0.5
5.3 ± 0.3
EP 5
5.1 ± 0.3
5.9 ± 0.4
5.5 ± 0.3
5.2 ± 0.4
EP 10
5.0 ± 0.3
6.1 ± 0.4
5.7 ± 0.3
4.9 ± 0.2
E′/A′
EP 2.5
1.44 ± 0.09
1.46 ± 0.09
1.53 ± 0.11
1.59 ± 0.08
EP 5
1.63 ± 0.10
1.55 ± 0.10
1.58 ± 0.12
1.57 ± 0.14
EP 10
1.50 ± 0.08
1.38 ± 0.08
1.53 ± 0.11
1.66 ± 0.07
MVGs (s)
EP 2.5
2.61 ± 0.17
2.04 ± 0.19
1.94 ± 0.30
1.72 ± 0.18a
EP 5
2.38 ± 0.34
1.79 ± 0.28
1.86 ± 0.29
1.56 ± 0.18
EP 10
1.94 ± 0.13
1.71 ± 0.23
1.77 ± 0.27
1.60 ± 0.25
MVGe (s)
EP 2.5
−1.74 ± 0.34
−2.38 ± 0.61
−2.47 ± 0.58
−2.54 ± 0.58
EP 5
−1.44 ± 0.19
−1.62 ± 1.00
−2.44 ± 0.56
−2.48 ± 0.43
EP 10
−1.71 ± 0.26
−2.21 ± 0.26
−2.58 ± 0.20
−2.24 ± 0.38
MVGa (s)
EP 2.5
−1.19 ± 0.24
−0.36 ± 0.92
−0.64 ± 0.51
−1.01 ± 0.47
EP 5
−0.58 ± 0.73
−1.45 ± 0.30
−0.69 ± 0.58
−0.60 ± 0.43
EP 10
−0.93 ± 0.16
−1.01 ± 0.17
−1.24 ± 0.17
−1.34 ± 0.34
Each value represents the mean ± standard error (). EP 2.5, 5, and 10: eplerenone 2.5, 5, and 10 mg/kg, respectively. aValue differs significantly from the baseline (time 0) value at .
