Review Article

Inflammatory Cytokines in Systemic Lupus Erythematosus

Table 1

IL-17 exerts effects on several cell types and tissues.

T cellsInduces production of proinflammatory IL-6, IL-1beta, and IL-21, providing a feedback loop [148]
Enhances recruitment of T cells to inflamed tissue [155]

B cellsDrives B-cell differentiation into plasma cells and production of autoantibodies [158, 159]

MonocytesEnhances migration to inflamed tissue [173]

Epithelial/
endothelial cells
Induces increased production of chemokines and upregulation of adhesion molecules [152]

NeutrophilsEnhances migration to inflamed tissue [154]