BioMed Research International / 2011 / Article / Tab 1 / Review Article
Protective Role of Cytotoxic T Lymphocytes in Filovirus Hemorrhagic Fever Table 1 ZEBOV protein sequences recognized by murine CD8
+ T cells. The table is adapted and expanded from [
97 ].
ZEBOV protein Epitope sequence Amino acid position Restriction Protectivea Reference Glycoprotein VSTGTGPGAGDFAFHK 141–155 H-2d Yes [96 , 98 ] LYDRLASTVI 161–169 H-2d NT [25 , 86 , 98 ] EYLFEVDNL 231–239 H-2d NT [25 , 98 ] WIPYFGPAAEGIYTE 531–545 H-2b No [86 , 96 ] TELRTFSI 577–584 H-2k NT [99 ] Nucleoprotein VYQVNNLEEIC 44–52 H-2b Yes [37 , 96 , 100 ] GQFLFASL 148–156 H-2b Yes [96 ] FLSFASLFL 150–159 HLA-A2.1 NT [101 ] RLMRTNFLI 202–210 HLA-A2.1 NT [101 ] SFKAALSSLA 279–287 H-2d Yes [96 , 100 ] FQQTNAMVT 388–396 H-2b NT [100 ] KLTEAITAA 404–412 HLA-A2.1 NT [101 ] DAVLYYHMM 663–671 H-2b Yes [96 ] VP24 KFINKLDALH 159–168 H-2d Yes NYNGLLSSI 171–179 H-2d Yes [96 ] PGPAKFSLL 214–222 H-2d Yes VP30 KFSKSQLSLLCETHLR 181–196 H-2d Yes H-2b Yes DLQSLIMFITAFLNI 231–245 H-2d Yes [96 ] H-2b Yes VP35 CDIENNPGL 45–53 H-2b Yes MVAKYDHL 138–145 H-2b Yes TVPQSVREAFNNL 190–202 H-2d Yes [96 ] RNIMYDHL 225–323 H-2b Yes PGFGTAFHQLVQVICK 233–248 H-2d Yes VP40 LRIGNQAFLQEFVLPP 150–165 H-2b Yes [86 , 96 ] AFLQEFVLPPVQLPQ 160–175 H-2d Yes [96 ] YFTFDLTALK 171–180 H-2d Yes [86 , 96 ] TESPEKIQAI 232–241 H-2d Yes [86 , 96 ]
a Protection from lethal challenge demonstrated by either peptide vaccination or by adoptive transfer experiments (Yes, >50% protection observed). NT: Not tested.