TY - JOUR A2 - Jia, Guang AU - Alipoor, Mohammad AU - Maier, Stephan E. AU - Gu, Irene Yu-Hua AU - Mehnert, Andrew AU - Kahl, Fredrik PY - 2015 DA - 2015/12/28 TI - Optimal Experiment Design for Monoexponential Model Fitting: Application to Apparent Diffusion Coefficient Imaging SP - 138060 VL - 2015 AB - The monoexponential model is widely used in quantitative biomedical imaging. Notable applications include apparent diffusion coefficient (ADC) imaging and pharmacokinetics. The application of ADC imaging to the detection of malignant tissue has in turn prompted several studies concerning optimal experiment design for monoexponential model fitting. In this paper, we propose a new experiment design method that is based on minimizing the determinant of the covariance matrix of the estimated parameters (D-optimal design). In contrast to previous methods, D-optimal design is independent of the imaged quantities. Applying this method to ADC imaging, we demonstrate its steady performance for the whole range of input variables (imaged parameters, number of measurements, and range of b-values). Using Monte Carlo simulations we show that the D-optimal design outperforms existing experiment design methods in terms of accuracy and precision of the estimated parameters. SN - 2314-6133 UR - https://doi.org/10.1155/2015/138060 DO - 10.1155/2015/138060 JF - BioMed Research International PB - Hindawi Publishing Corporation KW - ER -