Effects of Etanercept against Transient Cerebral Ischemia in Diabetic Rats

Figure 3

Effects of ETN on neurological deficits induced by cerebral ischemia in non-DM and DM rats. Assessment of neuronal damage after ischemia in non-DM (a) and DM (b) rats was determined by neurological score. Postischemic neurological deficits were evaluated at 2 h of MCAO and various ETN administration conditions after reperfusion. The shaded column is the MCAO-vehicle group; the closed column is the MCAO/Re-vehicle group; the open column is the MCAO-ETN group; the hatched column is the MCAO/Re-ETN group. Data are the means ± SDs (–6). and 0.01 versus corresponding values for the MCAO/Re-vehicle group. DM, diabetes mellitus; ETN, etanercept; MCAO/Re, middle cerebral artery occlusion/reperfusion.

(a) Non-DM

(b) DM