The Antidiabetic Effect of Low Doses of Moringa oleifera Lam. Seeds on Streptozotocin Induced Diabetes and Diabetic Nephropathy in Male Rats
Table 1
Effect of treating diabetic rats with Moringa seeds powder for 4 weeks on lipid peroxide and antioxidants enzymes in serum and kidney tissue homogenate.
Parameters
Statistics
G1 −ve control
G2 +ve control
G3 50 mg Moringa
G4 100 mg Moringa
Serum MDA nmol/mL
Mean ± SE LSD 0.05 = 0.180
2.19 ± 0.05a
6.14 ± 0.08d
3.50 ± 0.04c
4.36 ± 0.05b
-test
−32.1
25.2
24.1
Tissue MDA nmol/g kidney tissue
Mean ± SE LSD 0.05 = 0.450
3.375 ± 0.11a
11.18 ± 0.26d
7.60 ± 0.02b
6.18 ± 0.05c
-test
−27.3
12.7
19.3
Serum catalase U/L
Mean ± SE LSD 0.05 = 0.119
2.66 ± 0.05a
0.24 ± 0.01c
1.40 ± 0.03d
1.82 ± 0.02b
-test
44.1
−30.4
−54.3
Tissue catalase U/g kidney tissue
Mean ± SE LSD 0.05 = 0.178
4.13 ± 0.11a
0.44 ± 0.00c
1.89 ± 0.02d
2.72 ± 0.02b
-test
32.2
62.2
−88.3
Serum SOD U/mL
Mean ± SE LSD 0.05 = 14.698
664.20 ± 4.06a
352.00 ± 5.15c
446.55 ± 5.20d
577.15 ± 4.76b
-test
44.8
−11.2
−26.5
Tissue SOD U/g kidney tissue
Mean ± SE LSD 0.05 = 10.575
1124.7 ± 4.79a
421.63 ± 1.95d
624.30 ± 2.34c
819.33 ± 3.86b
-test
109.4
−69.7
−93.8
GSH U/mL
Mean ± SE LSD 0.05 = 1.369
26.11 ± 0.63a
9.80 ± 0.30c
15.50 ± 0.24d
18.88 ± 0.45b
-test
18.2
−15.1
−14.9
GSH U/g kidney tissue
Mean ± SE LSD 0.05 = 3.215
64.30 ± 1.24a
27.50 ± 0.77d
36.63 ± 0.88c
50.01 ± 1.45b
-test
32.7
−10.6
−12.0
Data are represented as mean ± SE. -test values; < 0.001. ANOVA analysis: within each row, means with different superscript (a, b, c, or d) are significantly different at < 0.05, whereas means superscripts with the same letters mean that there is no significant difference at < 0.05. LSD: least significant difference.