Research Article

The Antidiabetic Effect of Low Doses of Moringa oleifera Lam. Seeds on Streptozotocin Induced Diabetes and Diabetic Nephropathy in Male Rats

Table 1

Effect of treating diabetic rats with Moringa seeds powder for 4 weeks on lipid peroxide and antioxidants enzymes in serum and kidney tissue homogenate.

ParametersStatisticsG1
−ve control
G2
+ve control
G3
50 mg
Moringa
G4
100 mg
Moringa

Serum MDA
nmol/mL
Mean ± SE
LSD 0.05 = 0.180
2.19 ± 0.05a6.14 ± 0.08d3.50 ± 0.04c4.36 ± 0.05b
-test−32.125.224.1

Tissue MDA
nmol/g
kidney tissue
Mean ± SE
LSD 0.05 = 0.450
3.375 ± 0.11a11.18 ± 0.26d7.60 ± 0.02b6.18 ± 0.05c
-test−27.312.719.3

Serum catalase
U/L
Mean ± SE
LSD 0.05 = 0.119
2.66 ± 0.05a0.24 ± 0.01c1.40 ± 0.03d1.82 ± 0.02b
-test44.1−30.4−54.3

Tissue catalase
U/g
kidney tissue
Mean ± SE
LSD 0.05 = 0.178
4.13 ± 0.11a0.44 ± 0.00c1.89 ± 0.02d2.72 ± 0.02b
-test32.262.2−88.3

Serum SOD
U/mL
Mean ± SE
LSD 0.05 = 14.698
664.20 ± 4.06a352.00 ± 5.15c446.55 ± 5.20d577.15 ± 4.76b
-test44.8−11.2−26.5

Tissue SOD
U/g
kidney tissue
Mean ± SE
LSD 0.05 = 10.575
1124.7 ± 4.79a421.63 ± 1.95d624.30 ± 2.34c819.33 ± 3.86b
-test109.4−69.7−93.8

GSH
U/mL
Mean ± SE
LSD 0.05 = 1.369
26.11 ± 0.63a9.80 ± 0.30c15.50 ± 0.24d18.88 ± 0.45b
-test18.2−15.1−14.9

GSH U/g
kidney tissue
Mean ± SE
LSD 0.05 = 3.215
64.30 ± 1.24a27.50 ± 0.77d36.63 ± 0.88c50.01 ± 1.45b
-test32.7−10.6−12.0

Data are represented as mean ± SE. -test values; < 0.001. ANOVA analysis: within each row, means with different superscript (a, b, c, or d) are significantly different at < 0.05, whereas means superscripts with the same letters mean that there is no significant difference at < 0.05. LSD: least significant difference.