Computational Study of Correlated Domain Motions in the AcrB Efflux Transporter

Figure 1

Simulated system with AcrB (in black together with highlighted regions in additional colors) embedded in a lipid bilayer (in grey). The light green and yellow colored domains in the background denote the porter domains of L and O monomers, respectively. The subdomains of the porter domain in the foreground (monomer T) are colored individually: PC1 blue, PC2 red, PN1 orange, and PN2 dark green. In addition, transmembrane helices 2 and 8 of T monomer (left and right helices, resp.) are colored magenta.