Insulin-Like Growth Factor System in Cancer: Novel Targeted Therapies

Figure 7

Various strategic approaches to targeting IGF-1R receptors. Small-molecule TKIs, inactivating anti-IGF-1R antibodies, reduction or elimination of IGF-1R, protein expression by blocking IGF-1R, transcription (with triple helix) or translation (antisense technology and siRNA), IGF-1R, and mutants lacking beta-subunits (dominant-negative receptors).